生殖医学杂志2025，Vol.34Issue(7)：875-880,6.DOI:10.3969/j.issn.1004-3845.2025.07.001
生长激素对卵巢储备功能减退患者体外受精胚胎移植助孕结局的影响
The effect of growth hormone on pregnancy outcomes of IVF/ICSI-ET in patients with diminished ovarian reserve
摘要
Abstract
Objective:To investigate the clinical efficacy of growth hormone(GH)on pregnancy outcomes of IVF/ICSI-ET in patients with diminished ovarian reserve(DOR). Methods:A retrospective analysis of clinical data of 271 DOR patients w ho underwent IVF/ICSI-ET in the Department of Reproductive Medicine,Jining No.1 People's Hospital from January 2021 to May 2024 was conducted.Based on whether recombinant human growth hormone was used in the luteal phase after ovulation in the previous cycle,the patients were divided into GH group(n=157)and the control group(n=114).The number of oocytes retrieved,M Ⅱ oocytes,two pronuclei(2PN)fertilized oocytes,high-quality embryo,and the clinical pregnancy rate,the early miscarriage rate,the implantation rate,cumulative live birth rate etc.were compared between the two groups. Results:There were no significant differences in basic characteristics between two groups,including age,the duration of infertility,body mass index(BMI),anti-Müllerian hormone(AMH)level,basal antral follicle count(AFC)and basic endocrine level(P＞0.05).Compared with the control group,the GH group showed a significant decrease in the total amount of gonadotropins(Gn)and the duration of Gn use(P＜0.05),a significant increase in E2 level and a significant decrease in LH level on trigger day(P＜0.05),and a significant increase in the number of oocytes retrieved,M Ⅱ oocytes,2PN,and high-quality embryos(P＜0.05).However,there were no significant differences in endometrial thickness and type between the two groups on trigger day(P＞0.05).As for the pregnancy outcomes,the cumulative clinical pregnancy rate(43.31％vs.28.95％),cumulative implantation rate(39.89％vs.18.86％)and cumulative live birth rate in GH group were significantly higher than those of the control group,while early miscarriage rate in fresh embryo transfer cycle and cumulative early miscarriage rate were significantly lower in GH group than those in the control group(P＜0.05). Conclusions:Recombinant GH can improve the clinical outcomes of IVF/ICSI-ET by optimizing the quality of embryo,increasing cumulative clinical pregnancy rate and decreasing early miscarriage rate.关键词
生长激素/卵巢储备功能减退/体外受精-胚胎移植/妊娠结局Key words
Growth hormone/Ovarian reserve function/IVF/ICSI-ET/Pregnancy outcome分类
医药卫生引用本文复制引用
李倩,刘宇宁,乔岩岩..生长激素对卵巢储备功能减退患者体外受精胚胎移植助孕结局的影响[J].生殖医学杂志,2025,34(7):875-880,6.基金项目
济宁市重点研发计划项目(2023YXNS018) （2023YXNS018）
