生殖医学杂志2025，Vol.34Issue(7)：881-885,5.DOI:10.3969/j.issn.1004-3845.2025.07.002
重组人生长激素注射液在早发性卵巢功能不全患者中的疗效
The treatment efficacy of recombinant human growth hormone in patients with premature ovarian insufficiency
罗薇薇 1石明华 1万江帆 1钟长晔 1李洁 1黄卡立1
作者信息
- 1. 广西壮族自治区生殖医院生殖医学二科,南宁 530029
- 折叠
摘要
Abstract
Objective:To investigate the potential of recombinant human growth hormone(GH)in improving the pregnancy outcomes of infertile patients with premature ovarian insufficiency(POI)undergoing assisted reproductive technology(ART).
Methods:A total of 648 patients diagnosed with POI at the Reproductive Hospital of Guangxi Zhuang Autonomous Regionl from May 2022 to August 2024 were selected as study subjects.Patients were divided into two groups based on whether GH was added during the controlled ovarian stimulation(COS)process:group A(GH added,n=78)and group B(no GH added,n=570).The study compared the data of the two groups,including baseline characteristics,the COS strategy,the fertilization status and pregnancy outcomes.
Results:There were no significant differences between the two groups in terms of age,body mass index(BMI),the duration of infertility,baseline number of follicles,and baseline levels of hormonal indicators[FSH,LH,estradiol(E2)](P＞0.05),fertilization methods.In terms of the COS strategy,the antagonist protocol was the most common in both groups.Group A had significantly lower LH levels on the initiating day,higher initiating doses,higher total gonadotropin(Gn)usage and higher numbers of oocytes retrieved when compared with group B(P＜0.05).In terms of fertilization,group A had a significantly higher number of fertilized oocytes and a significantly lower rate of high-quality embryos on Day 3 when compared with group B(P＜0.05).There was no significant difference in clinical pregnancy rates between the two groups(23.53％vs.17.02％,P＞0.05).
Conclusions:In the ART process for patients with POI,GH can increase the number of both oocytes retrieved and fertilized oocytes,but it does not significantly improve clinical pregnancy outcomes.The impact of GH on clinical outcomes in POI patients requires further exploration.关键词
早发性卵巢功能不全/重组人生长激素注射液/获卵数/优胚率/妊娠结局Key words
Premature ovarian insufficiency/Recombinant human growth hormone injection/Number of oocytes retrieved/High-quality embryo rate/Pregnancy outcome分类
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罗薇薇,石明华,万江帆,钟长晔,李洁,黄卡立..重组人生长激素注射液在早发性卵巢功能不全患者中的疗效[J].生殖医学杂志,2025,34(7):881-885,5.
