生殖医学杂志2025，Vol.34Issue(7)：919-926,8.DOI:10.3969/j.issn.1004-3845.2025.07.008
黄体早期卵巢过度刺激综合征相关预测因素研究
Study on predictive factors of ovarian hyperstimulation syndrome in early luteal phase
摘要
Abstract
Objective:To explore the predictive factors for the risk of moderate to severe ovarian hyperstimulation syndrome(OHSS)after the use of HCG trigger in controlled ovarian stimulation(COS). Methods:A retrospective analysis was conducted on the data of 6 373 patients who underwent controlled ovarian stimulation(COS)and obtained 10 oocytes after using HCG trigger in the Department of Reproductive Center of Maternal & Child Health Care of Guangxi Zhuang Autonomous Region from January 2016 to December 2023.Among them,124 patients developed moderate to severe OHSS.Based on baseline data,1∶1 propensity matching was conducted between patients with moderate to severe OHSS(OHSS group)and those without moderate to severe OHSS(control group),with 119 cases in each group.The relationships between the number of oocytes retrieved as well as white blood cell count(WBC),platelet count(PLT),hematocrit(HCT),maximum ovarian diameter(MOD),and ascites grade in the early luteal phase within 3 days after oocyte retrieval and the occurrence of moderate to severe OHSS were analyzed.The predictive power of relevant indicators for OHSS through receiver operating characteristic(ROC)curve was evaluated and the optimal cutoff value was determined. Results:The number of oocytes retrieved as well as HCT,MOD,ascites grade in the early luteal phase within 3 days after oocyte retrieval were independent factors of OHSS(P＜0.05).The optimal cutoff values for predicting moderate to severe OHSS were more than 20 of oocytes retrieved,HCT＞42.85％,and MOD＞76.50 mm.The combined prediction of four indicators including the number of oocytes retrieved,HCT,MOD,and more than 2 of ascites grade within 3 days after oocyte retrieval showed the highest efficacy[the area under the curve(AUC)=0.808]in predicting the occurrence of moderate to severe OHSS in patients undergoing COS with not less than 10 of retrieved oocytes. Conclusions:The combination of four indicators in terms of the number of oocytes retrieved,HCT,MOD and more than 2 of ascites grade within 3 days after oocyte retrieval had good predictive value for the occurrence of moderate to severe OHSS in patients who underwent IVF/ICSI and obtained not less than 10 oocytes using HCG triggers in COS.关键词
卵巢过度刺激综合征/IVF/ICSI/控制性卵巢刺激/HCG扳机/黄体早期Key words
Ovarian hyperstimulation syndrome/IVF/ICSI/Controlled ovarian stimulation/HCG trigger/Early luteal phase分类
医药卫生引用本文复制引用
李艳娟,覃爱平,蒙亚晴,周红..黄体早期卵巢过度刺激综合征相关预测因素研究[J].生殖医学杂志,2025,34(7):919-926,8.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20230339) （Z-A20230339）
