天津中医药2025，Vol.42Issue(7)：829-838,10.DOI:10.11656/j.issn.1672-1519.2025.07.04
基于隐结构模型和关联分析探究射血分数保留心力衰竭中医证候特征
Exploring the syndrome regularity of HFpEF in traditional Chinese medicine based on latent structure model and association rules
摘要
Abstract
[Objective]To explore the distribution characteristics of traditional Chinese medicine(TCM)syndromes in HFpEF and provide references for individualized syndrome differentiation and treatment in clinical practice.[Methods]Diagnostic information was collected from HFpEF patients in the cardiology departments of six tertiary hospitals in Tianjin,forming a retrospective syndrome database.Lantern 5.0 software and a two-step hidden tree analysis algorithm were used to construct a latent structural model,and common syndromes in HFpEF were extracted through comprehensive clustering.The distribution relationships of HFpEF syndrome elements were analyzed using Apriori association analysis in SPSS Modeler 18.0 and network analysis in Cytoscape(3.10.2).Furthermore,integrating syndrome,symptom,and herbal medicine information from the SymMap database and network pharmacology,a systematic HFpEF disease-syndrome-symptom-herb network was constructed.[Results]A total of 364 HFpEF patients were included,with 72 symptoms,7 disease-location syndrome elements,and 14 disease-nature syndrome elements collected.The disease-location syndrome elements,ranked by degree centrality,were the heart(40),stomach(32),spleen(32),lung(30),kidney(28),and liver(28).The disease-nature syndrome elements were qi deficiency(36),blood stasis(36),phlegm(34),yin deficiency(28),water retention(26),dampness(26),yang deficiency(24),heat(24),and cold(20).By intersecting the results of the latent structural model and Apriori association analysis,five common TCM syndromes of HFpEF were identified:heart-lung qi deficiency syndrome,heart-kidney yang deficiency syndrome,heart blood stasis syndrome,qi deficiency-blood stasis syndrome,and phlegm-blood stasis syndrome.[Conclusion]By integrating the latent structural model and association rules,six disease-location syndrome elements,nine disease-nature syndrome elements,and five TCM syndromes of HFpEF were identified.The study clarified the syndrome characteristics of underlying deficiency with superficial excess in HFpEF and revealed its pathological evolution pattern of"deficiency-stasis-water accumulation".These findings provide a syndrome-based foundation for individualized TCM clinical treatment strategies for HFpEF.关键词
HFpEF/隐结构模型/关联规则/中医证候/数据挖掘Key words
HFpEF/latent structure/association rule/TCM syndromes/data mining分类
医药卫生引用本文复制引用
邓帅帅,李琳,林静怡,冯浡烜,樊官伟..基于隐结构模型和关联分析探究射血分数保留心力衰竭中医证候特征[J].天津中医药,2025,42(7):829-838,10.基金项目
国家自然科学基金项目(82274436) （82274436）
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202207). （ZYYCXTD-C-202207）
