天津中医药2025，Vol.42Issue(7)：839-843,5.DOI:10.11656/j.issn.1672-1519.2025.07.05
柴胡疏肝散联合莫沙必利对糖尿病胃轻瘫患者临床症状及肠道菌群丰度的影响
Impacts of Chaihu Shugan Powder combined with mosapride citrate on clinical symptoms and intestinal flora abundance in patients with diabetic gastroparesis
摘要
Abstract
[Objective]To explore the impacts of Chaihu Shugan Powder combined with mosapride citrate(MC)on clinical symptoms and intestinal flora abundance in patients with diabetic gastroparesis(DGP).[Methods]From January 2022 to December 2023,the 120 DGP patients who visited hospital were separated into a Western medicine group and a combined group stochastically,with 60 patients in each group.The Western medicine group received MC treatment,while the combined group received Chaihu Shugan Powder combined with MC treatment.The efficacy,TCM syndrome scores,gastric emptying rate,gastrointestinal hormones,blood glucose levels,inflammatory factors,and abundance of gut microbiota in both groups were observed after treatment.[Results]The total effective rate of the combined group after treatment was 95.00％,which was obviously higher than the Western medicine group's 80.00％(P＜0.05).After treatment,the scores of postprandial fullness,acid reflux,nausea and vomiting,and abdominal pain in both groups were prominently reduced compared to before treatment,and the combined group was prominently lower than the Western medicine group(P＜0.05).After treatment,the gastric emptying rate and IL-10 level in both groups obviously increased compared to before treatment,and the combined group was obviously higher than the Western medicine group(P＜0.05).The levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),motilin(MTL),gastrin(GAS),fasting blood glucose,and 2-hour postprandial blood glucose in both groups obviously decreased,while the combined group was prominently lower than the Western medicine group(P＜0.05).After treatment,the abundances of Firmicutes,Actinobacteria,Verrucomycota and Proteobacteria in both groups decreased prominently compared to before treatment,and the combined group was obviously lower than the Western medicine group(P＜0.05).[Conclusion]The combination of Chaihu Shugan Powder and MC has a prominent effect on DGP patients,which can alleviate clinical symptoms,improve clinical efficacy,promote gastric emptying rate,improve intestinal hormones,gut microbiota abundance,and blood glucose levels,and reduce inflammatory reactions.关键词
柴胡疏肝散/莫沙必利/糖尿病胃轻瘫/临床疗效/肠道菌群丰度Key words
Chaihu Shugan Powder/mosapride/diabetic gastroparesis/clinical efficacy/gut microbiota abundance分类
医药卫生引用本文复制引用
苏创泽,单崇武,牛艳艳,靳桂春..柴胡疏肝散联合莫沙必利对糖尿病胃轻瘫患者临床症状及肠道菌群丰度的影响[J].天津中医药,2025,42(7):839-843,5.基金项目
山西省中医药管理局科研课题(2022ZYYZ031). （2022ZYYZ031）
