武警医学2025，Vol.36Issue(7)：553-557,5.
两样本孟德尔随机化法对虚弱症与骨关节炎的因果关系分析
A causal relationship study between frailty syndrome and osteoarthritis using two-sample Mendelian randomization
付万里 1张田 1骆阳田 1李明浩1
作者信息
- 1. 450052 郑州,武警河南总队医院骨科
- 折叠
摘要
Abstract
Objective To analyze the causal relationship between frailty syndrome and osteoarthritis.Methods From the aggregated data of genome‑wide association studies(GWAS)published in 2021,tool variables closely related to frailty syndrome were obtained and screened.GWAS data for osteoarthritis and knee osteoarthritis from the Finnish database were selected.Two‑sample Mendelian randomization(MR)analysis was used to evaluate the association between frailty syndrome and osteoarthritis,knee osteoar‑thritis,and to conduct sensitivity analysis.Results A total of 24 SNPs were identified as significantly associated with frailty syn‑drome,16 SNPs as significantly associated with osteoarthritis,and 16 SNPs as significantly associated with knee osteoarthritis.When frailty syndrome was the exposure and osteoarthritis was the outcome variable,the IVW method and the Weighted median method both showed that frailty syndrome was associated with an increased risk of osteoarthritis(P<0.05),and sensitivity analysis showed hetero‑geneity(P<0.05),but no horizontal pleiotropy;when frailty syndrome was the exposure and knee osteoarthritis was the outcome vari‑able,the IVW method and the Weighted median method both showed that frailty syndrome was associated with an increased risk of knee osteoarthritis(P<0.05),and sensitivity analysis showed heterogeneity(P<0.05),but no horizontal pleiotropy.Conclusions Frailty syndrome can increase the risk of patients developing osteoarthritis.关键词
虚弱症/骨关节炎/因果关系/孟德尔随机化Key words
frailty syndrome/osteoarthritis/causal relationship/Mendelian randomization分类
医药卫生引用本文复制引用
付万里,张田,骆阳田,李明浩..两样本孟德尔随机化法对虚弱症与骨关节炎的因果关系分析[J].武警医学,2025,36(7):553-557,5.
