外科理论与实践2025，Vol.30Issue(2)：101-105,5.DOI:10.16139/j.1007-9610.2025.02.02
类器官研究在生物学获益为主的胆道恶性肿瘤诊疗中的意义
Role of organoid research in the biological benefit-dominated diagnosis and treatment of biliary tract carcinoma
齐中 1程石1
作者信息
- 1. 首都医科大学附属北京天坛医院普通外科,北京 100070
- 折叠
摘要
Abstract
Biliary tract carcinoma(BTC)is a highly malignant tumor with a poor prognosis.Although radical surgical resection remains the only curative treatment,only 20%of patients are eligible for curative resection.In recent years,comprehensive treatments combining chemotherapy with immunotherapy and targeted therapy,have become a key strategy in the current biological benefit-dominated therapeutic paradigm for BTC.However,the efficacy of these multimodal treatments remains suboptimal and heavily relies on precise individualized drug screening and response evaluation.The emerging tumor organoid technology faithfully recapitulates the histomorphological features and growth behavior of tumors,providing a novel platform for screening tumor-specific biomarkers.By enhancing tumor identification and margin delineation,this approach facilitates precise preoperative staging and optimize surgical planning.Furthermore,drug sensitivity testing based on patient-derived organoids enables personalized treatment strategies,demonstrating significant clinical value in improving comprehensive therapy for BTC.关键词
胆道恶性肿瘤/类器官/生物学获益/综合治疗Key words
Biliary tract carcinoma(BTC)/Organoid/Biological benefit/Comprehensive treatments分类
医药卫生引用本文复制引用
齐中,程石..类器官研究在生物学获益为主的胆道恶性肿瘤诊疗中的意义[J].外科理论与实践,2025,30(2):101-105,5.
