现代医药卫生2025，Vol.41Issue(7)：1569-1574,6.DOI:10.3969/j.issn.1009-5519.2025.07.007
低密度脂蛋白胆固醇对脑小血管病患者轻度认知功能障碍的诊断价值研究
Thevalueof low-density lipoproteincholesterol in the diagnosis of mildcognitive impairment in patients with cerebralsmallvessel disease
摘要
Abstract
Objective To investigate the diagnostic value of low-density lipoprotein cholesterol(LDL-C)for mild cognitive impairment(MCI)in patients with cerebral small vessel disease.Methods A total of 360 patients with cerebralsmall vascular disease(CSVD)who met the diagnostic criteria in the department of Neu-rology of our hospital from October 2019 to October 2021 were retrospectively collected.According to the MoCA scoring criteria,all patients were divided into the vascular mild cognitive impairment(VMCI)group(MoCA score between 18 and 26 points)and the non-VMCI group(MoCA score reached or exceeded 26 points),with 180 cases in each group.Compare the general demographic data and risk factors for cerebrovas-cular disease between two groups of patients,use binary logistic regression analysis to identify potential risk factors,and use ROC receiver operating curve to determine the diagnostic threshold of LDL-C for mild cogni-tive impairment in patients with cerebral small vessel disease.Results In terms of general demographic data,there was no significant difference in gender and BMI between the VMCI group and the non-VMCI group(P>0.05),but compared with the non-VMCI group,the VMCI group was older and the education level was lower(P<0.05).In terms of cerebral vascular disease risk factors,VMCI group had a higher proportion of previous lipoprotein metabolic syndrome,and during hospital treatment,systolic blood pressure(SBP),LDL-C and tro-ponin I(TnI)levels were higher,fasting blood glucose(Glu)levels were lower,with statistical significance(P<0.05).The sensitivity and specificity of lipid metabolic syndrome,SBP,fasting glucose Glu,LDL-C and TnI to predict VMCI were 0.328,0.761,0.994,0.656,0.489 and 0.794,0.428,0.005,0.611 and 0.728,re-spectively.The above statistically significant factors were replaced by binary logistics regression analysis,which showed that age,years of education,LDL-C and TnI were all independent risk factors for VMCI.Among them,higher levels of age,LDL-C and TnI would increase the risk of mild cognitive impairment,and higher years of education would increase the risk of mild cognitive impairment.Reduced risk of developing mild cog-nitive impairment.The ROC receiver operating curve showed that the AUC of the multivariable combined pre-diction model of MCI was 0.738(0.687-0.789),the sensitivity was 0.750 and the specificity was 0.633.Con-clusion LDL-C level has high diagnostic value in predicting mild cognitive impairment in patients with cere-bral small vascular disease.关键词
低密度脂蛋白胆固醇/脑小血管病/血管认知障碍/诊断Key words
Low-density lipoprotein cholesterol/Cerebral small vessel disease/Vasular cognitive impairment/Diagnosis分类
医药卫生引用本文复制引用
陈莉,伍绍强,汪顺利,张巧玉,钟华..低密度脂蛋白胆固醇对脑小血管病患者轻度认知功能障碍的诊断价值研究[J].现代医药卫生,2025,41(7):1569-1574,6.基金项目
重庆市卫生健康委员会科卫联合项目(2019MSXM108) （2019MSXM108）
重庆医科大学教育教学改革研究项目(JY20230341) （JY20230341）
重庆市公共卫生重点专科(学科)建设经费资助项目. （学科）
