现代医药卫生2025，Vol.41Issue(7)：1578-1583,6.DOI:10.3969/j.issn.1009-5519.2025.07.009
无神经系统并发症的新生儿高胆红素血症远期神经心理发育影响评估
Evaluation of the long-term neuropsychological development impact of neonatal hyperbilirubinemia without neurological complications
摘要
Abstract
Objective To investigate the effects of neonatal hyperbilirubinemia without neurological complications on cognitive and behavioral development in school-age children.Methods A total of 21 children with neonatal hyperbilirubinemia(NHB)without neurological complications who were diagnosed and hospi-talized in Yunyang People's Hospital of Danyang City from November 2014 to December 2017 were selected as the jaundice group.During the same period,23 healthy full-term infants born in the obstetrics and gynecology department of the hospital were selected for follow-up observation.When the children were 6 to 10 years old,they were evaluated by the Combined Chinese Third Revision of the Riven Intelligence Test(CRT-C3),the Diagnostic and Statistical Manual of Mental Disorders(4th Edition)(DSM-IV)Attention Deficit Hyperactivi-ty Disorder Diagnostic Scale,the Conners Parental Symptom Questionnaire(PSQ),and the Achenbach Child Behavior Scale(CBCL).The χ2 test was adopted for the count data;If the measurement data conformed to the normal distribution,the comparison between the two groups of data was conducted using the two-independent sample t-test.If it does not conform to the normal distribution,the Mann-Whitney U test is used to analyze the influence of NHB on the long-term cognitive and neuropsychological development of children.Results There were 21 children in the jaundice group,including 13 males and 8 females,with an average age of(8.05±0.59)years.There were 23 cases in the control group,including 12 males and 11 females,with an average age of(7.56±1.12)years.The assessment result of CRT-C3:The IQ value of the jaundice group was 112.28±3.04,and that of the control group was 112.26±2.15.There was no statistically significant differ-ence(P>0.05).The assessment results of the Attention Deficit and Hyperactivity Disorder(ADHD)DSM-Ⅳ Diagnostic Scale:In the jaundice group,4(19.48%)children had abnormalities,among which 2 cases(9.52%)were of the attention deficit type and 2 cases(9.52%)were of the hyperactivity and impulsivity types.In the control group,4 cases(17.39%)of children had abnormalities,all of which were of the attention deficit type.The second part(hyperactivity and impulsivity)in the jaundice group was higher than that in the control group,and the difference was statistically significant(P=0.032).The PSQ assessment results:The three factors,factorⅠ(conduct problem),factorⅣ(impulse hyperactivity),and factorⅥ(hyperactivity in-dex),were higher in the jaundice group than in the control group,and the differences were statistically signifi-cant(P=0.018,0.010,0.006).CBCL assessment results:The total scores of 2 children in the jaundice group exceeded the upper limit of the normal value.FactorⅥ(social withdrawal)and factorⅦ(hyperactivity)in the jaundice group were both higher than those in the control group,and the differences were statistically signifi-cant(P=0.023,0.001).Conclusion Neonatal hyperbilirubinemia without neurological complications in the neonatal period has no obvious impact on later intelligence.However,it can lead to more behavioral problems in children during the school-age period,with an increased occurrence of hyperactivity and impulsivity symp-toms in ADHD,as well as an increased incidence of neuropsychological abnormalities including conduct prob-lems and social withdrawal.关键词
高胆红素血症/认知/神经心理发育Key words
Hyperbilirubinemia/Cognitive/Neuropsychological development分类
医药卫生引用本文复制引用
张志华,程剑,周伟,王静,陈梦莹..无神经系统并发症的新生儿高胆红素血症远期神经心理发育影响评估[J].现代医药卫生,2025,41(7):1578-1583,6.基金项目
丹阳市科技局重点研发计划(社会发展)项目(SSF202216). （社会发展）
