现代医药卫生2025，Vol.41Issue(7)：1589-1593,5.DOI:10.3969/j.issn.1009-5519.2025.07.011
特应性皮炎与过敏性鼻炎的双向双样本孟德尔随机化研究
A two-way two-sample Mendelian randomization study of atopic dermatitis and allergic rhinitis
摘要
Abstract
Objective To explore the causal relationship between atopic dermatitis(AD)and allergic rhinitis(AR)by two-way two-sample Mendelian randomization(MR)analysis.Methods Based on the pub-licly available genome-wide association study(GWAS)data,this study selected genetic variants associated with AD and AR as instrumental variables,and used inverse variance weighting(IVW),weighted median(WM)and MR-Egger to evaluate causality.Heterogeneity test,sensitivity analysis and pleiotropic analysis were also performed.Results MR analysis results showed that there was a significant positive causal relation-ship between AD and AR(IVW OR=1.03,95%CI 1.01-1.05,P=0.002),and there was also a significant positive correlation between AR and AD(IVW OR=13.63,95%CI 6.11-30.39,P<0.001).In the two ana-lyses,the selected instrumental variables did not show pleiotropicity,and sensitivity analysis confirmed the stability of MR analysis results.Conclusion Through two-way two-sample MR analysis,it is proved that there is a significant causal relationship between AD and AR,which provides a theoretical basis for clinical combined prevention and treatment.关键词
特应性皮炎/过敏性鼻炎/因果关系/孟德尔随机化Key words
Atopic dermatitis/Allergic rhinitis/Causality/Mendelian randomization分类
医药卫生引用本文复制引用
吴小驰,倪晓东,王凯健..特应性皮炎与过敏性鼻炎的双向双样本孟德尔随机化研究[J].现代医药卫生,2025,41(7):1589-1593,5.基金项目
南通市卫生健康委员会科研课题青年指令性项目(QN2023062). （QN2023062）
