协和医学杂志2025，Vol.16Issue(4)：812-816,5.DOI:10.12290/xhyxzz.2025-0479
靶向胃泌素释放肽受体的核医学精准诊疗
Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor
摘要
Abstract
The gastrin-releasing peptide receptor(GRPR)is highly expressed in various malignant tumors(e.g.,glioblastoma,prostate cancer,and breast cancer)and has emerged as an important molecular target for precision cancer diagnosis and therapy.In recent years,the combined application of radionuclide-la-beled GRPR ligands with positron emission tomography/computed tomography(PET/CT)has achieved ground-breaking progress in noninvasive diagnosis,accurate staging,and therapeutic monitoring of GRPR-positive tumors.Meanwhile,GRPR-targeted radionuclide therapeutics have demonstrated significant therapeutic potential and promising clinical applications in trials.This GRPR-based theranostic strategy pioneers a novel ap-proach for precision medicine in GRPR-overexpressing tumors.关键词
胃泌素释放肽受体/放射性药物/诊断/治疗Key words
gastrin-releasing peptide receptor/radiopharmaceutical/diagnosis/therapy分类
医药卫生引用本文复制引用
王荣玺,朱朝晖,陈小元..靶向胃泌素释放肽受体的核医学精准诊疗[J].协和医学杂志,2025,16(4):812-816,5.基金项目
National Natural Science Foundation of China(82272046) （82272046）
National High Level Hospital Clinical Research Fun-ding(2025-PUMCH-D-003,2022-PUMCH-C-004) （2025-PUMCH-D-003,2022-PUMCH-C-004）
CAMS Innovation Fund for Medical Sciences(2024-I2M-ZH-001) 国家自然科学基金(82272046) （2024-I2M-ZH-001）
中央高水平医院临床科研专项(2025-PUMCH-D-003,2022-PUMCH-C-004) （2025-PUMCH-D-003,2022-PUMCH-C-004）
中国医学科学院医学与健康科技创新工程(2024-I2M-ZH-001) （2024-I2M-ZH-001）
