协和医学杂志2025，Vol.16Issue(4)：817-825,9.DOI:10.12290/xhyxzz.2025-0433
肿瘤骨转移精准治疗新进展
New Advances in Precision Treatment for Bone Metastasis of Tumors
摘要
Abstract
Bone metastasis,as a common terminal event in patients with advanced malignant tumors,significantly impacts patients'quality of life and survival prognosis,posing a major clinical challenge in the field of oncology.With the deepening understanding of tumor biology,the treatment paradigm for bone metastasis has progressively shifted from traditional palliative care to precise targeted interventions.Currently,clinical treatment strategies have demonstrated diversified development,with various therapeutic approaches-including radiotherapy,immunotherapy,bone-modifying agents,and small-molecule targeted drugs—achieving notable clinical progress.However,existing treatment regimens still face challenges such as significant interindividual variability in efficacy,frequent drug resistance,and prominent adverse effects.This article systematically reviews the latest advances in precision therapy for bone metastasis,provides an in-depth analysis of the strengths and limitations of different treatment strategies,and offers perspectives on future research directions and therapeutic prospects,aiming to provide reference for optimizing clinical practice and promoting translational research.关键词
肿瘤/骨转移/放疗/免疫治疗/骨改良药/靶向药物Key words
tumor/bone metastasis/radiotherapy/immunotherapy/bone-modifying agents/targeted drugs分类
医药卫生引用本文复制引用
梁安南,樊浩,邢金毅,郑志发,赵丽娜,吴志宏,邱贵兴..肿瘤骨转移精准治疗新进展[J].协和医学杂志,2025,16(4):817-825,9.基金项目
国家重点研发计划(2022YFC2703901) （2022YFC2703901）
中国工程院国家自然科学基金委联合战略研究与咨询项目(2024-ZCQ-18) （2024-ZCQ-18）
国家自然科学基金(82172525,82402760) （82172525,82402760）
北京市自然科学基金(7244389) （7244389）
中国医学科学院医学与健康科技创新工程(2021-I2M-1-052) （2021-I2M-1-052）
中央高水平医院临床科研专项(2022-PUMCH-D-002) National Key Research and Development Program of China(2022YFC2703901) （2022-PUMCH-D-002）
Strategic Research and Consulting Project of the Chinese Academy of Engineering(2024-ZCQ-18) （2024-ZCQ-18）
National Natural Science Foundation of China(82172525,82402760) （82172525,82402760）
Beijing Natural Science Foundation(7244389) （7244389）
CAMS Innovation Fund for Medical Sciences(2021-I2M-1-052) （2021-I2M-1-052）
National High Level Hospital Clinical Research Funding(2022-PUMCH-D-002) （2022-PUMCH-D-002）
