影像组学联合生物标志物预测肝癌微血管侵犯的研究进展OA北大核心
Research Progress of Radiomics Combined with Biomarkers for Predicting Microvascular Invasion in Liver Cancer
微血管侵犯是影响肝癌患者预后的重要因素之一,术前对其发生情况进行准确预测对于临床个体化治疗决策的制订具有重要意义.传统诊断主要依赖术后组织病理学结果进行评估,存在一定滞后性,而影像组学特征与生物标志物联合应用为微血管侵犯的术前预测提供了新思路.基于影像组学和生物标志物的术前预测模型,可从宏观影像学特征与微观分子层面精准解析,并高效预测微血管侵犯的发生风险,为临床决策提供多维度、精准化的科学依据.
Microvascular invasion is one of the critical factors influencing the prognosis of patients with hepatocellular carcinoma.Accurate preoperative prediction for its occurrence holds pivotal significance for the formulation of clinical individualized treatment decisions.Traditional diagnosis primarily relies on the evaluation of postoperative histopathological results,which exhibits a certain degree of lag.However,the emergence of radiomics features and biomarkers offers new insights for the preoperative prediction of mi-crovascular invasion.The preoperative prediction model based on radiomics and biomarkers is capable of precisely analyzing and efficiently predicting the occurrence risk of microvascular invasion from both macro-scopic imaging features and microscopic molecular levels,thereby providing multi-dimensional and precise scientific evidence for clinical decision-making.
梁静慧;王铭;陈婉婷;张宝璐荷;杜顺达;杨萌
中国医学科学院北京协和医学院研究生院,北京 100005||中国医学科学院北京协和医院超声医学科,北京 100730中国医学科学院北京协和医院超声医学科,北京 100730中国医学科学院北京协和医学院研究生院,北京 100005||中国医学科学院北京协和医院超声医学科,北京 100730中国医学科学院北京协和医学院研究生院,北京 100005||中国医学科学院北京协和医院肝脏外科,北京 100730中国医学科学院北京协和医院肝脏外科,北京 100730中国医学科学院北京协和医院超声医学科,北京 100730
医药卫生
微血管侵犯影像组学生物标志物肝癌精准诊疗
microvascular invasionradiomicsbiomarkershepatocellular carcinomaprecision diagnosis and treatment
《协和医学杂志》 2025 (4)
826-835,10
国家自然科学基金联合基金项目(U22A2023)国家自然科学基金青年科学基金项目(A类)[原国家杰出青年科学基金项目](62325112)国家重点研发计划项目(2023YFC2411705)中央级公益性科研院所基本科研业务费项目(2024-RC320-02)中央高水平医院临床科研专项(2022-PUMCH-D-002,2022-PUMCH-C-009) National Natural Science Foundation of China(U22A2023)National Natural Science Foundation of China(Grade A)[National Science Fund for Distinguished Young Scholars of China](62325112)National Key Research and Devel-opment Program of China(2023YFC2411705)Fundamental Research Funds for the Central Public-interest Scientific Institution of Chinese Academy of Medical Sciences(2024-RC320-02)National High Level Hospital Clinical Research Funding(2022-PUMCH-D-002,2022-PUMCH-C-009)
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