协和医学杂志2025，Vol.16Issue(4)：836-846,11.DOI:10.12290/xhyxzz.2025-0065
类器官技术在中枢神经系统肿瘤研究中的应用
The Application of Organoid Technology in the Research of Central Nervous System Tumors
摘要
Abstract
In recent years,organoid technology has emerged as a pivotal tool in central nervous system(CNS)tumor research.By recapitulating the 3D architecture,molecular profiles,and dynamic interactions of tumors with their microenvironment,it provides an innovative platform for elucidating disease mechanisms and facilitating drug screening.Brain organoids are primarily utilized to model normal neurodevelopmental processes and investigate CNS disease pathogenesis,whereas CNS tumor organoids are chiefly employed to simulate tumor heterogeneity and therapeutic responses.This review delineates the methodologies for establishing brain organoids and CNS tumor organoid models,along with their applications in CNS oncology research,with parti-cular emphasis on the technical features and advantages of pluripotent stem cell-derived,patient-derived,and xenograft-derived organoid models.Furthermore,it examines current challenges in model standardization,mi-croenvironment recapitulation,and ethical considerations pertaining to human tissue sources.Future directions for advancing this technology are also discussed.关键词
类器官技术/中枢神经系统肿瘤/发病机制/药物筛选Key words
organoid technology/central nervous system tumors/pathogenesis/drug screening分类
医药卫生引用本文复制引用
王子聪,赵雅慧,苑可欣,赵元立..类器官技术在中枢神经系统肿瘤研究中的应用[J].协和医学杂志,2025,16(4):836-846,11.基金项目
中央高水平医院临床科研专项(2023-PUMCH-E-011) National High Level Hospital Clinical Research Funding(2023-PUMCH-E-011) （2023-PUMCH-E-011）
