畜牧兽医学报2025，Vol.56Issue(7)：3071-3079,9.DOI:10.11843/j.issn.0366-6964.2025.07.003
赖氨酸乙酰化修饰在鸡精液冷冻中的保护作用及机制研究进展
Research Advances in the Investigation of the Protective Role of Lysine Acetylation in Chicken Semen Cryopreservation and Its Mechanism
摘要
Abstract
China has a rich diversity of chicken breeds with 140 native breeds,which harbor numerous excellent genetic traits.The conservation,breeding,and utilization of chicken genetic resources are of significant importance for promoting the independent development of national chicken breeding industry.The ultra-low temperature cryopreservation of semen is one of the most practical techniques for the long-term preservation and efficient utilization of livestock and poultry genetic resources.The semen cryopreservation technology for livestock,particularly for cattle,is relatively well-developed,but the technology was limited in chicken due to the long tails and small heads of spermatozoa,which result in poor freeze resistance.The poor fertility and sustained fertilization ability of chicken frozen sperm limited the application of semen cryopreservation technique in conservation and breeding.Post-translational modification of proteins was an important regulatory pathway through which cells respond to internal and external environmental stimuli.In mature sperm,both transcription and translation activities were largely halted,lysine acetylation modification of proteins might play crucial roles during the cryopreservation of chicken semen.These modifications could be essential for maintaining sperm structural integrity,mitochondrial function stability,and DNA integrity.However,the specific mechanisms underlying these effects remain unclear.This review aimed to provide a reference for investigating the role of lysine acetylation in the cryopreservation of chicken semen and establishing novel cryopreservation methods,and to offer theoretical insights and technical support for the efficient conservation of poultry genetic resources.关键词
鸡/冷冻精液/精子/赖氨酸乙酰化修饰/种质资源Key words
chicken/semen cryopreservation/sperm/lysine acetylation modification/germplasm resource分类
农业科技引用本文复制引用
宗云鹤,杨宇泽,孙研研,陈继兰,李云雷..赖氨酸乙酰化修饰在鸡精液冷冻中的保护作用及机制研究进展[J].畜牧兽医学报,2025,56(7):3071-3079,9.基金项目
国家自然科学基金(32302726) （32302726）
国家重点研发计划项目(2021YFD1200305) （2021YFD1200305）
北京市特色畜禽遗传资源保护项目(202203310002) （202203310002）
