畜牧兽医学报2025，Vol.56Issue(7)：3116-3128,13.DOI:10.11843/j.issn.0366-6964.2025.07.008
细菌双组分系统的耐药性及致病性研究进展
Advances in the Study of Drug Resistance and Pathogenicity of Bacterial Two-component Systems
摘要
Abstract
The bacterial two-component system(TCS)is a widespread signaling transduction pathway in organisms,which can sense and respond to physical,chemical,and biological stimuli inside and outside the cell,and induce a series of cellular responses through coupled sensing and regulatory mechanisms.TCS is the principal mechanism for bacteria to sense and respond to environmental signals and regulate physiological behaviors,which plays a crucial role in bacterial drug resistance,pathogenicity,biofilm formation,virulence factor regulation,etc.TCS regulates gene expression and cellular behaviors through the interactions of the two components(sensors and effectors)to handle the impact of adverse environment on bacteria,therefore achieving the goal of proliferation and invasion of the host.This paper reviews the research advances in the structure,function,drug resistance regulation and pathogenicity,and inhibitors of the two-component system,providing a reference for the development of novel antimicrobial drugs and bacterial prevention and control.关键词
双组分系统/结构/功能/耐药性/致病性Key words
two-component system/structure/function/drug resistance/pathogenicity分类
农业科技引用本文复制引用
向令娴,季倩宇,单新新,李琳..细菌双组分系统的耐药性及致病性研究进展[J].畜牧兽医学报,2025,56(7):3116-3128,13.基金项目
安徽省自然科学基金面上项目(2208085MC79) （2208085MC79）
安徽省高校自然科学重点科研项目(2024AH050468) （2024AH050468）
安徽农业大学高层次人才引进项目(rc392305) （rc392305）
