畜牧与兽医2025，Vol.57Issue(8)：49-60,12.
一种新型中药复方制剂对肉鸡生长性能、血清免疫指标及肠道菌群的影响
Impact of a new traditional Chinese medicine compound preparation on growth,immune response,and gut microbiota in broiler chickens
摘要
Abstract
This experiment was to investigate the effects of ginseng,Ophiopogon japonicus and other traditional Chinese medicine compound preparations on growth performance,serum immune indicators,and intestinal microflora in white-feathered broiler chickens.Initially,60 000 1-day-old healthy chickens were divided into two groups:the test group and the control group,with three replicates in each group and 10 000 chickens per replicate.In the test group,the traditional Chinese medicine compound preparation was administered in the drinking water for 15 days at dosages of 0.1 mL/chicken from days 1 to 5,0.2 mL/chicken from days 6 to 10,and 0.3 mL/chicken from days 11 to 15.The control group received no treatment during this period.On day 21,30 chickens from each group were randomly selected for sampling.Serum cytokines and immunoglobulins were collected from these chickens and were measured,and cecal microbial flora in them was analyzed.Then,mortality,culling rate,and weekly weight gains were calculated for all chickens,and the feed conversion ratio and the european per-formance index(EPI)were assessed at slaughter.The results showed that the broiler chickens in the test group exhibited a significantly high-er growth rate and average weekly weight gain from days 15 to 21,compared with the control group(P＜0.05).The total mortality rate of the birds from day 1 to day 21 was significantly reduced(P＜0.05),and the total mortality rate on day 42 was also significantly reduced(P＜0.05).The EPI was considerably higher in the test group(P＜0.05).Their serum levels of immunoglobulin G and gamma interferon were significantly increased,whereas the levels of interleukin-6 and interleukin-1β were significantly reduced(P＜0.05).Additionally,the tra-ditional Chinese medicine compound preparation improved the diversity of the cecal microbial community and enriched the microbial structure in the test group,compared with the control group.At the phylum level,the relative abundance of Firmicutes in the test group chickens in-creased,Bacteroidota decreased,and the Firmicutes to Bacteroidota ratio(F/B)rose significantly(P＜0.001).At the genus level,the rela-tive abundance of Bacteroides in the birds significantly decreased,whereas Alistipes and Faecalibacterium in them significantly increased,with Bacteroides and Alistipes showing the most notable changes.In summary,the traditional Chinese medicine compound preparation supplementa-tion in drinking water enhanced growth performance and immunity in the broiler chickens,improved their feed conversion rate,and reduced the risk of potential intestinal inflammation in them by modulating their intestinal microflora.关键词
中药复方制剂/肉鸡/生长性能/细胞因子/免疫球蛋白/肠道微生物菌群Key words
traditional Chinese medicine compound preparation/broiler/growth performance/cytokine/immunoglobulin/intestinal micro-flora分类
农业科技引用本文复制引用
徐江涛,武志勇,彭松,于亚明,林芳竹,马凤洲,陈瑞昶,王喜亮,李自力..一种新型中药复方制剂对肉鸡生长性能、血清免疫指标及肠道菌群的影响[J].畜牧与兽医,2025,57(8):49-60,12.基金项目
山东省重点研发计划(重大科技创新工程)项目(2022CXGC010606) （重大科技创新工程）
