新医学2025，Vol.56Issue(7)：706-714,9.DOI:10.12464/j.issn.0253-9802.2025-0060
过敏性鼻炎的中医药治疗机制及免疫调控途径研究
Study on the therapeutic mechanism of traditional Chinese medicine and immune regulation pathway of allergic rhinitis
摘要
Abstract
Allergic rhinitis(AR)is a type Ⅰ hypersensitivity reaction mediated by immunoglobulin E(IgE),involving multiple immune cells and inflammatory factors.Western medicine has achieved certain effects in alleviating AR symptoms,but its limitations have led more and more studies to focus on traditional Chinese medicine(TCM)treatment.According to TCM theory,the occurrence of AR is related to the dysfunction of the lung,spleen and kidney.The treatment principles include strengthening the body's resistance,eliminating pathogenic factors,clearing heat and detoxifying,and harmonizing Yin and Yang.Studies have shown that Chinese medicine exerts its immunomodulatory and anti-inflammatory effects by regulating the balance of T helper cells(Th)1/Th2,enhancing the function of regulatory T cells,inhibiting IgE-mediated allergic reactions,reducing inflammatory cell infiltration,and regulating NF-κB,MAPK and JAK/STAT signaling pathways.The multi-target mechanism of Chinese medicine in the treatment of AR provides an effective therapeutic strategy for symptom improvement and recurrence prevention.This article reviews the mechanism of action and related research progress of TCM in the treatment of AR,aiming to further optimize its clinical application value.关键词
过敏性鼻炎/中医药治疗/免疫调控/信号通路Key words
Allergic rhinitis/Traditional Chinese medicine treatment/Immune regulation/Signaling pathway引用本文复制引用
惠丹妮,黄文绘,毋莹,韩梦洁,陈璇羽,薛亚娟..过敏性鼻炎的中医药治疗机制及免疫调控途径研究[J].新医学,2025,56(7):706-714,9.基金项目
陕西省科技厅重点研发计划项目(2021SF-264) （2021SF-264）
陕西省卫生健康科研基金项目(2022D035) （2022D035）
延安大学2025年研究生教育创新计划项目(YKY2025012) （YKY2025012）
