右江医学2025，Vol.53Issue(6)：528-534,7.DOI:10.3969/j.issn.1003-1383.2025.06.008
2017-2023年广西某儿童医院新生儿金黄色葡萄球菌的临床分布及耐药性分析
Clinical distribution and drug resistance analysis of neonatal Staphylococcus aureus at a children's hospital in Guangxi from 2017 to 2023
摘要
Abstract
Objective To analyze the distribution characteristics,drug resistance status,and clinical features of neonatal Staphylococcus aureus(SA),so as to provide effective guidance for clinical diagnosis and scientific basis for the rational selection of antimicrobial drugs.Methods A retrospective analysis was conducted on the distribution of SA specimens isola-ted from 2017 to 2023 at the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region.WHONET 5.6 software was used to analyze the drug resistance of the specimens,and SPSS 25.0 software was used to compare antimicrobial resistance data and the clinical basic information of the patients.Results From 2017 to 2023,a total of 379 strains of SA were isolated from various clinical specimens of newborns in the hospital,with a methicillin-resistant Staphylococcus aureus(MRSA)detection rate of 22.43%.Among the 379 strains of SA,sputum specimens were the most common(accounted for 32.72%),followed by ocular secretions(accounted for 29.55%),nasal secretions(accounted for 13.98%),wound secre-tions(accounted for 11.87%),blood specimens(accounted for 5.54%),pus(accounted for 3.96%),and other types of specimens(accounted for 2.38%).In addition to being fully resistant to penicillin,the MRSA strains had a resistance rate of 58.8%to erythromycin,57.6%to azithromycin,56.5%to both clindamycin and clarithromycin,22.3%to tetracycline,and less than 10%to other commonly used antibiotics such as chloramphenicol.The resistance rates of MRSA to antimicrobi-al agents such as azithromycin,clindamycin,clarithromycin,erythromycin,and penicillin were all significantly higher than those of MSSA,and difference was statistically significant(P<0.05).Among neonates with MRSA infections,male infants accounted for 62.4%,infants aged 15-28 d accounted for 62.4%,term infants accounted for 90.5%,inpatients accoun-ted for 71.8%,and the main types of infections were pneumonia,conjunctivitis,and sinusitis,each with a proportion of more than 16%.In addition,the incidence of pneumonia caused by MRSA infection was significantly higher than that caused by MSSA infection(P<0.05).Conclusion Pneumonia is the main infection in neonatal SA at the hospital,and the detec-tion rate and proportion of MRSA in neonates differ significantly from previous reports in China,which may be related to fac-tors such as patient age and region.Due to limited options for empiric treatment of MRSA infections,strengthening preventive measures is crucial in reducing the spread of SA,especially MRSA infections.关键词
金黄色葡萄球菌/新生儿/抗生素/耐药性Key words
Staphylococcus aureus(SA)/neonate/antibiotic/drug resistance分类
医药卫生引用本文复制引用
邓蕊,梁嘉慧,李林霖,胡雪桦,李明艺..2017-2023年广西某儿童医院新生儿金黄色葡萄球菌的临床分布及耐药性分析[J].右江医学,2025,53(6):528-534,7.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20230303) （Z-A20230303）
广西壮族自治区临床重点专科建设项目(桂卫医发[2020]15号) （桂卫医发[2020]15号）
