中国医疗设备2025，Vol.40Issue(7)：33-39,7.DOI:10.3969/j.issn.1674-1633.20240878
射波刀放疗剂量递增对局部晚期胰腺癌疗效的影响研究
Study on the Effect of Increasing Dose of Cyberknife Radiotherapy on the Therapeutic Effect of Locally Advanced Pancreatic Cancer
摘要
Abstract
Objective To explore the effect of dose escalation of Cyberknife radiotherapy(referred to as"radiotherapy")on the therapeutic effect of locally advanced pancreatic cancer.Methods A total of 110 patients with locally advanced pancreatic cancer treated with Cyberknife at the Department of Radiotherapy of the 940th Hospital of Joint Logistic Support Force of PLA from January 2013 to June 2023 were selected as the research subjects and divided into 3 groups according to the radiotherapy dose:35,40,and 45 Gy.The median survival period and survival rate of the three groups were mainly observed.The local control rate and distant survival rate of the three groups were secondiously observed.The differences among the three groups were analyzed to see if they were statistically significant.Results The median survival time of 110 patients with locally advanced pancreatic cancer was 15 months.The 1-year survival rate was 65.2%(95%CI:55.9%-76.2%),and the 2-year survival rate was 36.4%(95%CI:26.4%-50.4%).The median survival periods of the 35,40,and 45 Gy groups were 11,20,and 25 months respectively,and the difference was statistically significant(x2=12.789,P=0.002<0.05).Compared with the 35 Gy group,the median survival time of the 40 Gy group was significantly prolonged,and the difference was statistically significant(20 months vs.11 months,x2=7.070,P=0.008<0.05),while there was no statistically significant difference between the 40 Gy group and the 45 Gy group(x2=0.744).P=0.388>0.05.The 1-year survival rates of the 35,40,and 45 Gy groups were 46.0%,64.9%,and 85.3%respectively;the 1-year local control rates were 48.4%,55.4%,and 67.6%respectively;and the 1-year distant transfer-free survival rates were 57.4%,74.5%,and 52.3%respectively.The differences in the maximum cross-sectional area and the tumor marker carbohydrate antigen 199 before and after treatment in 110 patients were statistically significant(P<0.05).The gastrointestinal toxic reactions and bone marrow toxic reactions of 110 patients were mainly grade 1 to 2.Conclusion With the increase of radiotherapy dose,the median survival time of patients with locally advanced pancreatic cancer treated with Cyberknife will gradually increase and will no longer increase after reaching a certain dose.With the increase of the total radiotherapy dose for patients with locally advanced pancreatic cancer,the local control rate will also increase,but the difference is not statistically significant.关键词
胰腺癌/射波刀/放疗剂量/生存率/局部控制率/无远转生存率Key words
pancreatic cancer/Cyberknife/radiotherapy dose/overall survival/local control rate/distant metastasis-free survival分类
医药卫生引用本文复制引用
张效亮,田种泽,朱向辉,刘晓娇,马小婷,张超..射波刀放疗剂量递增对局部晚期胰腺癌疗效的影响研究[J].中国医疗设备,2025,40(7):33-39,7.基金项目
甘肃省自然科学基金(22JR5RA003). （22JR5RA003）
