疑难病杂志2025，Vol.24Issue(7)：775-779,791,6.DOI:10.3969/j.issn.1671-6450.2025.07.002
血清Tenascin-C、Midkine在脓毒症并发心肌损伤患者中的表达及临床意义
The expression and clinical significance of serum Tenascin-C and Midkine in patients with sepsis complicated with myocardial injury
摘要
Abstract
Objective To investigate the expression and clinical significance of serum Tenascin-C and Midkine in pa-tients with sepsis complicated with myocardial injury(MI).Methods A total of 108 patients with sepsis(sepsis group)and 54 healthy volunteers(healthy control group)admitted to the Department of Emergency Medicine of Shaanxi Provincial People's Hospital from January 2019 to December 2024 were selected.Sepsis patients were divided into MI subgroup and non-MI sub-group according to whether they were complicated with MI.The levels of serum Tenascin-C and Midkine were detected by enzyme-linked immunosorbent assay;Multivariate unconditional Logistic regression analysis was used to analyze the factors of sepsis complicated with MI;ROC curve was used to analyze the predictive value of serum Tenascin-C,Midkine levels and other influencing indicators for sepsis complicated with MI.Results Compared with the healthy control group,the levels of serum Tenascin-C and Midkine in the sepsis group were increased(t=13.460,13.414,all P＜0.001);the incidence of MI in pa-tients with sepsis was 46.30％(50/108);Compared with the non-MI subgroup,the levels of serum Tenascin-C and Midkine in the MI subgroup were increased(t=5.783,5.410,P＜0.001).Sequential organ failure assessment(SOFA)score,creatine ki-nase isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide,Tenascin-C and Midkine were independent risk factors for sepsis complicated with MI[OR(95％CI)=1.169(1.015-1.348),1.685(1.247-2.277),1.003(1.001-1.004),1.342(1.134-1.589),1.616(1.194-2.186)];the areas under the curve of Tenascin-C,Midkine and their combination in predicting sepsis complicated with MI were 0.780,0.774 and 0.874,respectively,the combination of the two was superior to their respective predictive effi-cacy(Z/P=2.601/＜0.001,2.598/＜0.001).Conclusion The increase of serum Tenascin-C and Midkine levels is related to sepsis complicated with MI,and the combination of the two has a high predictive value for sepsis complicated with MI.关键词
脓毒症/心肌损伤/肌腱蛋白C/中期因子/预测Key words
Sepsis/Myocardial injury/Tenascin-C/Midkine/Prediction分类
医药卫生引用本文复制引用
武冬,郭筱王,贾佳,张骥,古春昱..血清Tenascin-C、Midkine在脓毒症并发心肌损伤患者中的表达及临床意义[J].疑难病杂志,2025,24(7):775-779,791,6.基金项目
陕西省重点研发计划项目(2023-YBSF-159) （2023-YBSF-159）
陕西省重点研发计划项目(2018SF-023) Key Research and Development Program of Shaanxi Province(2023-YBSF-159) （2018SF-023）
Key Research and Develop-ment Program of Shaanxi Province(2018SF-023) （2018SF-023）
