疑难病杂志2025，Vol.24Issue(7)：804-809,6.DOI:10.3969/j.issn.1671-6450.2025.07.007
急性缺血性脑卒中患者血清CTRP6、KLF10水平变化及与神经功能缺损程度的关系
The changes of serum CTRP6 and KLF10 levels in patients with acute ischemic stroke and their relationship with the degree of neurological deficits
摘要
Abstract
Objective To investigate the changes of serum complement C1q/tumor necrosis factor related protein 6(CTRP6)and Krüppel-like factor 10(KLF10)levels in patients with acute ischemic stroke(AIS)and their relationship with the degree of neurological deficits.Methods A total of 136 AIS patients admitted to the Department of Neurology in Mi-anzhu People's Hospital from January 2020 to July 2024 were selected as AIS group.According to the degree of neurological deficit[National Institutes of Health Stroke Scale(NIHSS)score],they were divided into mild subgroup(n=47),moderate subgroup(n=48)and severe subgroup(n=41).Another 68 healthy volunteers were selected as healthy control group.Serum levels of CTRP6 and KLF10 were detected by enzyme-linked immunosorbent assay.Spearman correlation analysis was used to analyze the correlation between serum CTRP6,KLF10 levels and NIHSS scores in AIS patients.Multivariate Logistic regres-sion analysis was used to analyze the influencing factors of severe neurological deficits in AIS patients.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficiency of serum CTRP6 and KLF10 levels for severe neuro-logical deficits in AIS patients.Results The serum CTRP6 level in the AIS group was lower than that in the healthy control group,and the KLF10 level was higher than that in the healthy control group(t/P=14.134/＜0.001,14.0374/＜0.001);age,cere-bral infarction volume,serum KLF10 level mild subgroup＜moderate subgroup＜severe subgroup,serum CTRP6 level mild subgroup＞moderate subgroup＞severe subgroup(F/P=31.995/＜0.001,568.359/＜0.001,84.772/＜0.001,75.117/＜0.001);Pearson correlation analysis showed that the NIHSS score of AIS patients was negatively correlated with serum CTRP6 level(rs/P=-0.759/＜0.001)and positively correlated with serum KLF10 level(rs/P=0.747/＜0.001);multivariate Logistic regression analysis showed that large cerebral infarction volume and high serum KLF10 level were independent risk factors for severe neurological deficits in AIS patients[OR(95％CI)=2.178(1.291-3.674),1.122(1.022-1.232)],and high serum CTRP6 level was an independent protective factor[OR(95％CI)=0.857(0.747-0.982)];the AUC of serum CTRP6,KLF10 levels and the combination of the two in the diagnosis of severe neurological deficits in AIS patients were 0.835,0.821 and 0.915,respec-tively.The combination of the two was better than the single diagnosis(Z/P=2.868/0.004,3.054/0.002).Conclusion The de-crease of serum CTRP6 level and the increase of KLF10 level in AIS patients are related to the aggravation of neurological deficits.The combination of serum CTRP6 and KLF10 levels has a high diagnostic efficiency for severe neurological deficits in AIS patients.关键词
急性缺血性脑卒中/补体C1q/肿瘤坏死因子相关蛋白6/Krüppel样因子10/神经功能缺损程度/诊断Key words
Acute ischemic stroke/Complement C1q/tumor necrosis factor-related protein 6/Krüppel-like factor 10/Neurological impairment degree/Diagnosis分类
医药卫生引用本文复制引用
范朝莉,陈卓,付伟,蒋瑀,彭洁,易鑫,游志科..急性缺血性脑卒中患者血清CTRP6、KLF10水平变化及与神经功能缺损程度的关系[J].疑难病杂志,2025,24(7):804-809,6.基金项目
四川省卫生健康科研课题普及项目(19PJ229) Sichuan Province Health and Health Research Project(19PJ229) （19PJ229）
