烟台大学学报（自然科学与工程版）2025，Vol.38Issue(3)：308-313,6.DOI:10.13951/j.cnki.37-1213/n.240307
血红蛋白-氯铂酸纳米粒的制备及体外功能评价
Preparation and in vitro Functional Evaluation of Hemoglobin-Chloroplatinic Acid Nanoparticles
摘要
Abstract
To lessen in vivo toxicity of nanoparticles and improve tumor targeting,a kind of PEG-hemoglobine-chlo-roplatinic acid nanoparticles(Hb NPs)with good biocompatibility was constructed for the first time.Hexachloro-platinic acid was used as an oxidant to catalyze the oxidative polymerization of pyrrole,and the nanoparticles were modified by polyethylene glycol(DSPE-PEG2000).Transmission electron microscopy(TEM)showed that the Hb NPs nanoparticles were spherical with uniform size.Their average particle size was(97.9±1.2)nm,and the po-tential was(-23.0±2.4)mV.Ultraviolet-visible absorption spectrum(UV-Vis)and inductively coupled plasma mass spectrometry(ICP)confirmed that hemoglobin and platinum acid were effectively doped in the nanoparticles.In vitro cytotoxicity and apoptosis experiments demonstrated that Hb NPs had low toxicity and good biocompatibili-ty.Therefore,Hb NPs are expected to reduce the deleterious and unfavorable effects on other healthy tissues,pro-viding a new research direction in the field of protein-based nanodrug carriers.关键词
血红蛋白/生物相容性/氧化聚合/纳米药物递送载体Key words
hemoglobin/biocompatibility/oxidative polymerization/drug delivery nanosystem分类
医药卫生引用本文复制引用
李静,张越,陈大全..血红蛋白-氯铂酸纳米粒的制备及体外功能评价[J].烟台大学学报（自然科学与工程版）,2025,38(3):308-313,6.基金项目
山东省自然科学基金资助项目(ZR2019ZD24). （ZR2019ZD24）
