空军军医大学学报2025，Vol.46Issue(7)：841-848,8.DOI:10.13276/j.issn.2097-1656.2025.07.001
宿主基因-环境暴露交互作用下的肿瘤发生发展机制
Mechanism of tumorigenesis and cancer progression under the interaction of host genes and environmental exposure
摘要
Abstract
As cancer research advances,its hallmark characteristics have been clearly defined.However,the molecular mechanisms underlying the systemic manifestations of tumors and their ultimate causes of mortality remain incompletely elucidated.The key to future research lies in revealing the interactions between tumors and distant organs,as well as how environmental factors and host physiology influence tumors and their hosts,which is critical for the prevention and treatment of cancer.This field of study centers on cancer as a systemic disease,covering aspects such as the driving forces of tumorigenesis and progression,the tumor microenvironment,the host's macro-immunological landscape,aging,metabolism and obesity,circadian rhythms,neuro-cancer interactions,and the host microbiome.In-depth investigation into the interaction between host genes and environmental factors will provide a theoretical foundation for cancer prevention,improvement of patients' quality of life,and enhancement of treatment efficacy.关键词
肿瘤微环境/肿瘤免疫学/细胞衰老/昼夜节律/微生物组/肿瘤代谢现象/基因-环境互作/多学科研究Key words
tumor microenvironment/cancer immunology/cellular senescence/circadian rhythm/microbiome/cancer metabolism phenomenon/gene-environment interaction/interdisciplinary research分类
医药卫生引用本文复制引用
陈志南,边惠洁,黄婉..宿主基因-环境暴露交互作用下的肿瘤发生发展机制[J].空军军医大学学报,2025,46(7):841-848,8.基金项目
国家自然科学基金重大研究计划-重点支持项目(82130084) （82130084）
