应用数学和力学2025，Vol.46Issue(7)：821-835,15.DOI:10.21656/1000-0887.450140
超声波激励细胞核振动响应分析
Vibration Dynamics for Cell Nuclei Under Ultrasonic Excitations
摘要
Abstract
The ultrasonic wave,owing to its non-invasiveness,precise targeting,and minimal side effects,has found extensive applications in clinical therapy.In recent years,tumor treatment utilizing ultrasonic exciting to induce vibration behaviors in cancer cell nuclei has drawn much attention.However,the dynamical characteris-tics and resonance mechanisms of cell nuclei,particularly under forced vibration,remain unclear.A model for cell nuclei was established to investigate the vibration responses under low-intensity ultrasonic excitations.Typ-ical lymphocytes(suspended cells),glial cells,and chondrocytes with different substrate stiffnesses were taken as examples.The results indicate that,the higher the frequency and intensity of ultrasonic excitation are,the larger the acoustic force acting on the cell nucleus will be.Under certain frequency and intensity of ultrason-ic excitation,the acoustic force acting on the cell nucleus will increase with the cell matrix stiffness.Ultrasonic excitation on cells can cause cell nuclear resonance,and the greater the cell matrix stiffness is,the higher the cell nuclear resonance frequency will be.The relative vibration amplitude of the cell nucleus decreases with the matrix stiffness,with lymphocytes having the largest resonance amplitudes,glial cells the next largest,and chondrocytes the smallest.This study provides a theoretical and analytical framework for ultrasound-excited cell nucleus vibration,and is conducive to promoting the development of ultrasound-based tumor mechanother-apy.关键词
细胞核/细胞骨架/超声波/激励/共振Key words
cell nucleus/cytoskeleton/ultrasonic/excitation/resonance分类
数理科学引用本文复制引用
丰玲琳,齐兵,刘少宝..超声波激励细胞核振动响应分析[J].应用数学和力学,2025,46(7):821-835,15.基金项目
国家自然科学基金(12272179 （）
11902155) （）
江苏省科技计划重点项目(BK20243058) （BK20243058）
