诊断学理论与实践2025，Vol.24Issue(2)：118-124,7.DOI:10.16150/j.1671-2870.2025.02.002
光子计数CT在肝脏疾病中的应用进展
Photon-counting CT in liver disease:applications and advances
摘要
Abstract
Photon-counting computed tomography(PCCT)represents a significant technological breakthrough in the field of CT imaging in recent years.This innovative technology utilizes novel semiconductor detectors to directly detect and count individual X-ray photons,enabling high-precision multi-energy data acquisition.Compared with traditional energy-integrating detector CT(EID-CT),PCCT offers significant technical advantages,including ultra-high spatial resolu-tion(with a minimum detector pixel size of 0.15×0.18 mm),improved contrast-to-noise ratio(CNR increase of 15%-45%),and substantial radiation dose reduction(20%-90%).Moreover,PCCT can generate standardized CT value images,ensu-ring stable and reproducible quantitative measurements suitable for tissue composition analysis.With its ability to acquire data across multiple energy bins,PCCT achieves true multi-energy spectral imaging.In liver diseases,PCCT enables non-enhanced quantification of hepatic fat and iron content,with 70 keV standardized CT values showing a strong correlation with MRI-derived proton density fat fraction(PDFF).During contrast-enhanced scans,PCCT significantly improves the detection rate and lesion margin delineation of hypovascular tumors and allows accurate enhancement quantification through iodine maps.Additionally,PCCT enables ultra-low-dose,one-stop imaging that simultaneously provides functional hemodynamic parameters of hepatic microcirculation and high-quality multiphasic monoenergetic CT images for clinical diagnosis and preoperative planning—without the need for additional contrast medium or supplementary triphasic scans.This dual benefit of low radiation and contrast dose supports its clinical utility in liver imaging.This review focuses on recent advances in the application of PCCT in the diagnosis and treatment of diffuse and neoplastic liver diseases,aiming to provide theoretical foundations and practical insights for its broader implementation in precision hepatology.关键词
光子计数CT/肝脏/多能量成像/虚拟单能量成像/灌注成像Key words
Photon-counting computed tomography/Liver/Multi-energy imaging/Virtual monoenergetic imaging/Perfusion imaging分类
医药卫生引用本文复制引用
李卫侠,严福华..光子计数CT在肝脏疾病中的应用进展[J].诊断学理论与实践,2025,24(2):118-124,7.基金项目
国家自然科学基金青年项目(81401406) （81401406）
"医+X"交叉学科(S202510248449) （S202510248449）
