诊断学理论与实践2025，Vol.24Issue(2)：163-169,7.DOI:10.16150/j.1671-2870.2025.02.007
基于光子计数探测器CT能谱定位像定量评估股骨颈骨密度的前瞻性研究
Prospective study on quantitative evaluation of femoral neck bone mineral density using spectral localizer radio-graph from photon-counting detector CT
周山税 1秦乐 2常蕊 2杜联军 2严福华 1刘方韬2
作者信息
- 1. 上海交通大学医学院附属瑞金医院放射科,上海 200025||上海交通大学医学院医学技术学院医学影像技术系,上海 200025
- 2. 上海交通大学医学院附属瑞金医院放射科,上海 200025
- 折叠
摘要
Abstract
Objective To evaluate the performance of spectral localizer radiograph(SLR)acquired by photon-counting detector CT(PCD-CT)for the quantitative assessment of areal bone mineral density(aBMD)in the femoral neck.Methods From July 2024 to April 2025,subjects(≥18 years old)scheduled for both dual-energy X-ray absorptiometry(DXA)and CT scans were prospectively enrolled.All subjects underwent PCD-CT examinations to obtain SLR,and two observers independently performed blinded measurements of the aBMD in the left femoral neck on the SLR.The measure-ment results of DXA were used as the reference standard to evaluate the quantitative accuracy of SLR for aBMD and its diagnostic performance for abnormal bone mass(T-score<-1.0).Results A total of 63 subjects(36 females)were enrolled,with a mean age of 64.30±13.20 years.The median aBMD measured by DXA was 0.889[interquartile range(IQR),0.749-1.031]g/cm2,and 23 subjects(36.51%)showed abnormal bone mass.The aBMD values measured by the two observers were 0.879(0.760-0.985)g/cm2 and 0.891(0.784-0.977)g/cm2,respectively.SLR-based measurements of aBMD demon-strated excellent inter-observer agreement(intraclass correlation coefficient=0.98).Using DXA results as the reference,the median absolute percentage error of aBMD measured by SLR was 6.66%(IQR,3.64%-9.80%).The diagnostic accu-racy,sensitivity,and specificity of SLR for diagnosing abnormal bone mass were 95.24%(50/63),95.65%(22/23),and 95.00%(38/40),respectively.Conclusions Spectral localizer radiographs acquired by PCD-CT can accurately quantify bone mineral density in the femoral neck and demonstrate high diagnostic performance for abnormal bone mass.关键词
光子计数CT/能谱成像/骨质疏松/定位像Key words
Photon-counting detector CT/Spectral imaging/Osteoporosis/Localizer radiograph分类
医药卫生引用本文复制引用
周山税,秦乐,常蕊,杜联军,严福华,刘方韬..基于光子计数探测器CT能谱定位像定量评估股骨颈骨密度的前瞻性研究[J].诊断学理论与实践,2025,24(2):163-169,7.
