中风与神经疾病杂志2025，Vol.42Issue(7)：605-609,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0115
神经免疫在偏头痛发生与慢性化过程中的作用
The role of neuroimmune interactions in the pathogenesis and chronicity of migraine
摘要
Abstract
Migraine is a debilitating neurological disorder commonly observed in clinical practice,and its pathogen-esis is closely associated with abnormal activation and sensitization of the trigeminovascular system.Recent studies have shown that neuroimmune interactions play a pivotal role in the pathophysiological process of migraine.This article system-atically reviews the multidimensional clinical evidence for the link between immune system dysregulation and the develop-ment of migraine,covering the aspects of genetic susceptibility,inflammatory factors in peripheral circulation,and neuro-imaging features of the central nervous system.Furthermore,this article discusses the latest research advances based on rodent animal models,which reveals the dynamic recruitment of diverse immunocompetent cells,including innate immune cells,adaptive immune cells,and neuroglial cells,across the hierarchical structures of the trigeminovascular pathway.These immune effector cells bidirectionally modulate neuronal excitability through the complex network of pro-inflammatory and anti-inflammatory mediators,thereby participating in the formation of peripheral and central sensitiza-tion.This article especially focuses on the potential application value of these fundamental research findings in clinical translation.关键词
偏头痛/发病机制/神经免疫Key words
Migraine/Pathogenesis/Neuroimmune interactions分类
医药卫生引用本文复制引用
陈俊玮,董铭,董天一,李一凡,仲芳田,张吴琼,莫多,施苗,吴百华,于澎..神经免疫在偏头痛发生与慢性化过程中的作用[J].中风与神经疾病杂志,2025,42(7):605-609,5.基金项目
吉林省自然科学基金面上项目(医学科学领域)(YDZJ202501ZYTS084) （医学科学领域）
吉林省卫生健康科技能力提升项目(2024A015) （2024A015）
国家重点研发项目子课题(2023YFC2508701) （2023YFC2508701）
