中国动脉硬化杂志2025，Vol.33Issue(6)：461-468,8.DOI:10.20039/j.cnki.1007-3949.2025.06.001
传统中药作为PPAR调节剂在动脉粥样硬化治疗中的应用
Application of traditional Chinese medicine for treatment of atherosclerosis via targe-ting PPAR
摘要
Abstract
Atherosclerosis is recognized as an inflammatory disease,and its development is regulated by multiple fac-tors,particularly dyslipidemia.Peroxisome proliferator-activated receptor(PPAR)regulate the expression of genes that are involved in lipid metabolism and inflammation;and they have three subfamily members including PPARα,PPARβ,and PPARγ.However,synthetic PPAR agonists exhibit ambiguous effects in atherosclerotic therapy and induce various side effects.Notably,recent studies demonstrate that traditional Chinese medicine(TCM)alleviate atherosclerotic cardiovascular diseases via suppressing hyperlipidemia and inflammation through regulation of PPAR signaling pathway.This article pri-marily reviews the regulatory effects of TCM on PPAR and their therapeutic effects on atherosclerosis,provides valuable in-formation for pharmacologists that are interested in searching for effective herbal prescriptions for atherosclerosis therapy and for clinicians that are interested in prevention and treatment of atherosclerotic cardiovascular diseases using TCM.关键词
传统中药/过氧化物酶体增殖物激活受体/脂质稳态/炎症/心血管疾病Key words
traditional Chinese medicine/peroxisome proliferator-activated receptor/lipid homeostasis/in-flammation/cardiovascular diseases分类
医药卫生引用本文复制引用
吴莹,张雪莹,郭守东..传统中药作为PPAR调节剂在动脉粥样硬化治疗中的应用[J].中国动脉硬化杂志,2025,33(6):461-468,8.基金项目
国家自然科学基金项目(82070469) （82070469）
