中国动脉硬化杂志2025，Vol.33Issue(6)：469-473,480,6.DOI:10.20039/j.cnki.1007-3949.2025.06.002
乳酸化修饰在心血管疾病发病机制中的作用
The role of lactylation modification in the pathogenesis of cardiovascular diseases
摘要
Abstract
Cardiovascular diseases(CVD)are common complex diseases caused by the interaction of genetic and environmental factors and are closely related to epigenetic modifications.Recent studies have found that lactylation modi-fication,a newly discovered epigenetic mechanism,regulates histones by adding lactyl groups to lysine residues,thereby promoting the transcription and expression of specific genes.Moreover,it also affects the structure and function of non-histone proteins and plays important roles in the pathogenesis of CVD such as atherosclerosis(As),myocardial infarction(MI),ischemia reperfusion injury(IRI)and heart failure(HF)by regulating protein function and gene expression.In this review,the author summarizes and elaborates on the relevant literature on the roles of lactylation modification in CVD published in recent years,in order to provide reference for future research.关键词
乳酸/乳酸化修饰/组蛋白乳酸化/心血管疾病/作用机制/表观遗传Key words
lactic acid/lactylation modification/histone lactylation/cardiovascular diseases/mechanism of action/epigenetics分类
医药卫生引用本文复制引用
周明学..乳酸化修饰在心血管疾病发病机制中的作用[J].中国动脉硬化杂志,2025,33(6):469-473,480,6.基金项目
国家自然科学基金项目(82274287) （82274287）
北京市自然科学基金项目(7232266) （7232266）
