中国动脉硬化杂志2025，Vol.33Issue(6)：531-538,8.DOI:10.20039/j.cnki.1007-3949.2025.06.010
转录因子SOX9在心血管系统中的作用研究进展
Research progress on the role of transcription factor SOX9 in cardiovascular system
摘要
Abstract
Cardiovascular disease is an important problem affecting global human health,and its incidence is in-creasing year by year.In recent years,more and more studies have shown that sex-determined region of Y(SRY)-related high mobility group-box 9(SOX9)gene,as a highly conserved transcription factor,is widely involved in regulating cardiac dvelopment and cardiovascular disease progression at the level of gene transcription.SOX9,alone or in combination with other proteins,can bind to corresponding cis-acting elements in the downstream target gene promoter region and participate in regulating the expression of downstream heart development or cardiovascular disease-related genes.Therefore,SOX9 has the potential to be a new therapeutic target for the cardiovascular system.In this paper,the structure and function of SOX9 were systematically described,and the latest research progress of SOX9 in cardiac remodeling and vascular remode-ling was summarized,in order to provide new ideas and methods for the prevention and treatment of cardiovascular system diseases in the future.关键词
心血管系统疾病/Y染色体性别决定区相关高迁移率组盒蛋白9/心脏发育/心脏重构/血管重塑Key words
cardiovascular diseases/SRY-related high mobility group-box9/cardiac development/cardiac remodeling/vascular remodeling分类
医药卫生引用本文复制引用
王慧莹,刘雨舒,赵勇,傅羽..转录因子SOX9在心血管系统中的作用研究进展[J].中国动脉硬化杂志,2025,33(6):531-538,8.基金项目
国家自然科学基金项目(81200143和82170513) （81200143和82170513）
哈尔滨医科大学附属第一医院院基金项目(2021M33) （2021M33）
