中国动脉硬化杂志2025，Vol.33Issue(7)：579-586,8.DOI:10.20039/j.cnki.1007-3949.2025.07.004
腹主动脉瘤的发病机制及防治策略研究进展
Recent advances in the pathogenesis and preventive strategies of abdominal aortic an-eurysm
摘要
Abstract
Abdominal aortic aneurysm(AAA)is characterized by a localized and irreversible enlargement of the abdominal aorta,which poses a significant risk to life in the event of rupture.Currently,the primary treatment for AAA is surgical intervention,as there are no effective pharmacological therapies available to prevent or slow postoperative vascular dilation.Therefore,understanding the detailed pathogenesis of AAA and identifying effective prevention and treatment strategies is essential.This review begins by examining the pathological and molecular mechanisms involved in AAA,fo-cusing on key research areas such as the phenotypic switching of vascular smooth muscle cells,inflammation and metabolic reprogramming.Based on a large of animal and clinical studies,this review then explores therapeutic strategies and prom-ising drugs for AAA,including mesenchymal stem cell therapy,nanomaterial applications,and immunomodulatory inter-ventions.The review aims to provide researchers with new ideas and directions for the prevention and treatment of AAA.关键词
腹主动脉瘤/血管平滑肌细胞/表型转换/炎症反应/代谢重编程Key words
abdominal aortic aneurysm/vascular smooth muscle cell/phenotypic switching/inflammation/metabolic reprogramming分类
医药卫生引用本文复制引用
雷青青,申子雯,孙梦贤,张亭亭..腹主动脉瘤的发病机制及防治策略研究进展[J].中国动脉硬化杂志,2025,33(7):579-586,8.基金项目
国家自然科学基金项目(82473913和82204384) （82473913和82204384）
深圳市科技计划项目(JCYJ20220530144417039) （JCYJ20220530144417039）
