中国动脉硬化杂志2025，Vol.33Issue(7)：602-608,7.DOI:10.20039/j.cnki.1007-3949.2025.07.007
辅酶Q10对动脉粥样硬化大鼠血脂水平和肠道菌群丰度的调控作用
The regulatory effects of coenzyme Q10 on blood lipid levels and intestinal flora abun-dance in atherosclerotic rats
摘要
Abstract
Aim To investigate the regulatory effects of coenzyme Q10(CoQ10)on blood lipid level and intesti-nal flora abundance in atherosclerotic(As)rats.Methods 24 rats were randomly divided into control group,As group and CoQ10 intervention group.Rats in the As group and CoQ10 intervention group were fed with high-fat chow for 2 weeks,combined with abdominal aortic balloon injury to replicate the As model.CoQ10 was administered by gavage start-ing on the next day of modeling,once daily for 4 weeks.Aortic Movat's staining and lipid levels were used to verify the effect of CoQ10 intervention in As,and the abundance of intestinal flora in intestinal contents was analyzed using met-agenomics.Results Compared with the control group,rat aortic tissues in the As group showed endothelial damage,structural disorganization of the internal elastic plate and inflammatory infiltration,serum triglyceride(TG),total cholester-ol(TC)and low density lipoprotein cholesterol(LDLC)levels were increased,and high density lipoprotein cholesterol(HDLC)levels were decreased.Compared with the As group,the structure of the endothelial cells of the aorta and the structure of the endothelial cells,the internal elastic plates and the smooth muscle cell morphology were relatively regular,serum TC,TG and LDLC levels were decreased,and HDLC levels were increased in the CoQ10 intervention group.Com-pared with the control group,the intestinal bacterial biodiversity in the As group was reduced.At the phylum level,the abundance of the Firmicutes and the Bacteroidetes were down-regulated,whereas that of Proteobacteria was up-regulated.At the genus level,the relative abundance of Lactobacillus,Bacteroides,Akkermansia,Limosilactobacillus,Parabacteroides and Ligilactobacillus was down-regulated,and the relative abundance of Muribaculum was up-regulated.Compared with the As group,CoQ10 intervention restored the biodiversity of the intestinal microbiota in As rats and increased the relative abundance of Firmicutes,Bacteroidetes,Lactobacillus,Bacteroides,Akkermansia,Limosilactobacillus,Parabacteroides and Ligilactobacillus,while reducing the relative abundance of Proteobacteria and Muribaculum(all P＜0.05).Conclusion CoQ10 can regulate blood lipid levels in As rats,upregulate the abundance of beneficial microbiota,downregulate the abun-dance of harmful microbiota,and modulate the diversity of the gut microbiota.关键词
动脉粥样硬化/肠道菌群/辅酶Q10/血脂水平Key words
atherosclerosis/intestinal flora/coenzyme Q10/blood lipid levels分类
医药卫生引用本文复制引用
王玉涛,杨丽科,王华雨,刘明..辅酶Q10对动脉粥样硬化大鼠血脂水平和肠道菌群丰度的调控作用[J].中国动脉硬化杂志,2025,33(7):602-608,7.基金项目
国家自然科学基金青年基金项目(82104860) （82104860）
山东省自然科学基金项目(ZR2022MH268) （ZR2022MH268）
山东省中医药科技发展计划项目(2019-0559) （2019-0559）
济南市卫生健康委员会科技计划项目(2019-1-23) （2019-1-23）
山东省医药卫生科技发展计划项目(2018WS478) （2018WS478）
济南市临床医学科技创新计划项目(202134013) （202134013）
济南市医疗卫生行业高层次人才专项经费资助(202412) （202412）
