中国动脉硬化杂志2025，Vol.33Issue(7)：609-617,9.DOI:10.20039/j.cnki.1007-3949.2025.07.008
单纯药物涂层球囊在假性冠状动脉左主干分叉病变中的疗效及安全性
The efficacy and safety of simple drug-coated balloon in the treatment of pseudo-left main bifurcation lesions of coronary arteries
摘要
Abstract
Aim To explore the safety and efficacy of simple drug-coated balloon(DCB)compared with provi-sional stenting(PS)in the treatment of pseudo-left main(pseudo-LM)bifurcation lesions.Methods A retrospective analysis was performed on 175 patients who underwent coronary angiography for pseudo-LM bifurcation lesions and interven-tional treatment at the Second Affiliated Hospital of Zhengzhou University from January 2018 to January 2023.According to the treatment strategy,they were divided into drug-eluting stent(DES)group(99 cases)and DCB group(76 cases).Preoperative and immediate postoperative quantitative coronary angiography(QCA)data were recorded,and patients were followed up.The follow-up endpoints included the occurrence of major adverse cardiovascular events(MACE)and hospi-tal re-admission.Coronary angiography and QCA data during follow-up were also recorded.Results The immediate postoperative minimum lumen diameter and lumen gain in the left main(LM),left anterior descending(LAD),and left circumflex(LCX)arteries of the DCB group were smaller than those of the DES group(P＜0.05),while the degree of re-sidual lumen stenosis immediately after surgery was greater than that of the DES group(P＜0.05).QCA was performed on the coronary angiography results of follow-up patients.The minimum lumen diameter in LM,LAD,and LCX was smaller in the DCB group than in the DES group during follow-up(P＜0.05).The degree of residual lumen stenosis dur-ing follow-up was greater in the DCB group than in the DES group(P＜0.05),but the late lumen loss in LM,LAD,and LCX was smaller in the DCB group than that in the DES group,with statistically significant differences(P＜0.05).There was no significant difference in the incidence of postoperative MACE between the two groups during the follow-up period(P＞0.05).Cox regression analysis showed that the choice of interventional treatment(DCB vs.PS)had no significant impact on the risk of MACE(P＞0.05).Conclusion Compared with PS,DCB alone demonstrates relatively satisfac-tory efficacy and safety in the treatment of pseudo-LM bifurcation lesions and can be considered as an alternative treatment strategy for interventional therapy of such lesions.关键词
冠心病/左主干分叉病变/药物涂层球囊/药物洗脱支架/血管内超声Key words
coronary heart disease/left main bifurcation lesions/drug-coated balloon/drug-eluting stent/intravascular ultrasound分类
医药卫生引用本文复制引用
邓蕴哲,祝万洁,万大国,张娟..单纯药物涂层球囊在假性冠状动脉左主干分叉病变中的疗效及安全性[J].中国动脉硬化杂志,2025,33(7):609-617,9.基金项目
河南省医学科技攻关计划项目(LHGJ20220438) （LHGJ20220438）
