中国动脉硬化杂志2025，Vol.33Issue(7)：618-624,7.DOI:10.20039/j.cnki.1007-3949.2025.07.009
RBP4、LDLC/Alb和MHR与颈动脉粥样硬化人群斑块稳定性的关系及其对缺血性脑卒中的预测价值
Correlation between RBP4,LDLC/Alb,MHR and plaque stability in carotid athero-sclerosis population and their predictive value for acute ischemic stroke
摘要
Abstract
Aim To analyze the correlation between serum retinol-binding protein 4(RBP4),low density lipo-protein cholesterol to albumin ratio(LDLC/Alb),monocyte to high density lipoprotein ratio(MHR)and plaque stability in carotid atherosclerosis population and their predictive value for acute ischemic stroke(AIS).Methods A total of 197 patients with asymptomatic carotid atherosclerosis admitted to our hospital from September 2021 to January 2023 were selected for a prospective cohort study,and they were categorized into occurred group and non-occurred group according to whether AIS occurred within 12 months.Baseline information at time of visit,results of the cervical ultrasonography and serum RBP4,LDLC/Alb,MHR levels were compared between the two groups.Spearman/Pearson and receiver operating characteristic(ROC)curve were used to analyze the corr-elation of RBP4,LDLC/Alb and MHR with carotid atherosclerosis and plaque stability,and the value of predicting AIS in carotid atherosclerosis population.Hosmer-Lemeshow goodness of fit test was used to evaluate the calibration ability of serum RBP4,LDLC/Alb and MHR to jointly predict AIS in carotid atherosclerosis population.Results The carotid intima-media thickness(IMT)was higher in occurred group than that in non-occurred group.There were more soft plaques and mixed plaques in occurred group than in non-occurred group(P＜0.05).Serum levels of RBP4,LDLC/Alb and MHR were higher in occurred group than those in non-occurred group(P＜0.05).The correlation analysis showed that the levels of serum RBP4,LDLC/Alb and MHR were positively correla-ted with IMT(r=0.803,0.740,0.710)and plaque properties(r=0.736,0.685,0.703)(P＜0.001).ROC curve a-nalysis showed that the AUC of serum RBP4,LDLC/Alb and MHR in predicting AIS in carotid atherosclerosis population was 0.796,0.821 and 0.828,respectively,and the AUC of MHR was the largest;the AUC of the combination of serum RBP4,LDLC/Alb and MHR was 0.936,which was higher than that of MHR(Z=2.978,P＜0.05),the predictive sensi-tivity and specificity were 88.24％and 87.40％.Hosmer-Lemeshow goodness of fit test showed that there was no signifi-cant difference between serum RBP4,LDLC/Alb and MHR in predicting AIS and the actual observation value in carotid atherosclerosis population(P＞0.05),and the prediction model had good calibration ability.Conclusion Serum RBP4,LDLC/Alb,and MHR are positively correlated with carotid atherosclerosis and plaque stability,and can predict the occurrence of AIS.Combined detection of the three can be used as a method for early identification of potential high-risk populations for AIS,providing a new,quantifiable guidance scheme for the prevention and treatment of AIS in carotid ath-erosclerotic population.关键词
视黄醇结合蛋白4/低密度脂蛋白胆固醇/白蛋白比值/单核细胞/高密度脂蛋白比值/颈动脉粥样硬化/斑块稳定性/缺血性脑卒中Key words
retinol binding protein 4/low density lipoprotein cholesterol to albumin ratio/monocyte to high density lipoprotein ratio/carotid atherosclerosis/plaque stability/acute ischemic stroke分类
医药卫生引用本文复制引用
张帆,赵博,张志伟,张丽平,苏慧芳,寇文辉..RBP4、LDLC/Alb和MHR与颈动脉粥样硬化人群斑块稳定性的关系及其对缺血性脑卒中的预测价值[J].中国动脉硬化杂志,2025,33(7):618-624,7.基金项目
河北省医学科学研究课题(20220591) （20220591）
张家口市科技计划自筹经费项目(2322146D) （2322146D）
