中国动脉硬化杂志2025，Vol.33Issue(7)：631-637,7.DOI:10.20039/j.cnki.1007-3949.2025.07.011
环境因子诱导产生的活性氧对载脂蛋白的修饰作用在动脉粥样硬化中的研究进展
Progress in the role of reactive oxygen species induced by environmental factors on apolipoproteins in atherosclerosis
摘要
Abstract
Environmental factors such as air pollutants,plastic micro-particles,ionizing radiation,and traffic noise promote the onset and progression of atherosclerotic cardiovascular disease(CVD)through mechanisms including inducing inflammatory responses,promoting oxidative stress,and accelerating lipid deposition.Notably,the modification of apoli-poprotein(Apo)by reactive oxygen species(ROS)accelerates this process.On one hand,ROS can oxidize key amino acid residues in Apo,altering its structure and thereby impairing its normal physiological function.On the other hand,ROS can induce lipid peroxidation of Apo,rendering the oxidized Apo more susceptible to recognition and uptake by macro-phages.This accelerates foam cell formation and drives the progression of atherosclerotic(As)plaques.This review summarizes recent research advances on the role of ROS-induced modification of Apo by environmental factors in atheroscle-rotic CVD.关键词
动脉粥样硬化/心血管疾病/载脂蛋白/环境因子/氧化应激Key words
atherosclerosis/cardiovascular disease/apolipoprotein/environmental factors/oxidative stress分类
医药卫生引用本文复制引用
刘意秋,王蕾,于杨,张继国..环境因子诱导产生的活性氧对载脂蛋白的修饰作用在动脉粥样硬化中的研究进展[J].中国动脉硬化杂志,2025,33(7):631-637,7.基金项目
国家自然科学基金面上项目(81970385) （81970385）
山东省自然科学基金面上项目(ZR2023MH361、ZR2019MH021) （ZR2023MH361、ZR2019MH021）
中国博士后科学基金面上项目(2022M721336) （2022M721336）
山东省医药卫生科技发展计划项目(202002040923) （202002040923）
泰安市科技发展计划引导项目(2020NS232) （2020NS232）
