中国动脉硬化杂志2025，Vol.33Issue(8)：645-654,10.DOI:10.20039/j.cnki.1007-3949.2025.08.001
乳酸及乳酸化修饰在心血管疾病中的研究进展
Research progress of lactate and lactylation in cardiovascular diseases
摘要
Abstract
Metabolic reprogramming plays a crucial role in the pathogenesis of cardiovascular diseases(CVD).Lactate,a metabolite of glycolysis,is now considered an important cellular signaling molecule involved in regulating various metabolic processes within the microenvironment.Recently discovered lactylation modifications have been found to play significant roles in CVD such as atherosclerosis(As),vascular or valve calcification,myocardial infarction,heart failure(HF),and pulmonary hypertension(PH).This review summarizes the regulatory mechanisms of lactate and lactylation modifications in these CVD,aiming to provide new insights for their precise prevention and treatment strategies.关键词
乳酸/乳酸化修饰/心血管疾病Key words
lactate/lactylation/cardiovascular diseases分类
医药卫生引用本文复制引用
杨艺清,姚玉宇,刘乃丰..乳酸及乳酸化修饰在心血管疾病中的研究进展[J].中国动脉硬化杂志,2025,33(8):645-654,10.基金项目
国家自然科学基金项目(82170478) （82170478）
