中国动脉硬化杂志2025，Vol.33Issue(8)：695-701,7.DOI:10.20039/j.cnki.1007-3949.2025.08.007
血清sST2水平与STEMI患者早期再灌注性心律失常的相关性
Correlation between serum sST2 level and early reperfusion arrhythmia in STEMI patients
摘要
Abstract
Aim To investigate the correlation between serum solube growth stimulation expressed gene 2 protein(sST2)and early reperfusion arrhythmia(ERA)after emergency percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A total of 202 STEMI patients who under-went emergency PCI from November 2020 to August 2022 in the Cardiac Center of Liaoning Provincial People's Hospital were divided into two groups based on the occurrence of ERA within 48 hours after PCI:ERA group and non-ERA group.Serum sST2 level and clinical data were compared between the groups.Univariable and multivariable Logistic regression analysis were used to explore the association between serum sST2 level and ERA occurrence,and restricted cubic spline model was applied to identify independent risk factors for ERA.Results There were 83(41.1％)patients experi-enced ERA within 48 hours after PCI.Compared with the non-ERA group,the patients in ERA group had shorter time from chest pain to reperfusion and higher serum sST2 level(P＜0.001).Multivariate Logistic regression analysis showed that for STEMI patients,elevated serum sST2 level(sST2≥45.03 μg/L),early reperfusion time(chest pain to successful reperfusion time≤5.23 h),high thrombosis burden,and right coronary artery as the infarct related artery(IRA)were in-dependent risk factors for ERA after emergency PCI.The restricted cubic spline model suggested that the serum sST2 lev-el of STEMI patients was nonlinearly correlated with the risk of ERA after PCI(P＜0.01),and the cutoff point was 45.12 μg/L.ROC curve analysis showed that the area under the ROC curve of serum sST2 level in predicting ERA oc-currence after PCI was 0.827(95％CI:0.771～0.883).Conclusion The high serum sST2 level before PCI is an independent risk factor for ERA occurrence after PCI in patients with STEMI.When serum sST2＞45.12 μg/L,its level is positively correlated with the risk of ERA.关键词
急性ST段抬高型心肌梗死/可溶性生长刺激表达基因2蛋白/再灌注性心律失常Key words
acute ST-segment elevation myocardial infarction/solube growth stimulation expressed gene 2 protein/reperfusion arrhythmia分类
医药卫生引用本文复制引用
车文菁,金雨彬,常淑敏,孙溢晗,王成福,侯爱洁..血清sST2水平与STEMI患者早期再灌注性心律失常的相关性[J].中国动脉硬化杂志,2025,33(8):695-701,7.基金项目
辽宁省联合基金面上资助计划项目(2023-MSLH-133) （2023-MSLH-133）
