中国肺癌杂志2025，Vol.28Issue(6)：434-440,7.DOI:10.3779/j.issn.1009-3419.2025.102.24
淋巴结清扫方式对非小细胞肺癌患者术后慢性咳嗽的影响
Effect of Lymph Node Clearance Modalities on Chronic Cough after Surgery in Non-small Cell Lung Cancer
摘要
Abstract
Background and objective Lung cancer has the highest mortality rate among all malignant tumors,and non-small cell lung cancer(NSCLC)accounts for about 80％-85％of all lung cancers.Lobectomy and lymph node dissec-tion are one of the most important treatment methods,and lymph node dissection,as an important part,has attracted much attention.And its mode and scope of dissection may affect postoperative complications,particularly the occurrence of chronic cough.The aim of this study is to investigate the effect of lymph node dissection on postoperative chronic cough in patients with NSCLC undergoing lobectomy,and to provide clinical evidence for optimizing surgical strategy and reducing postopera-tive chronic cough.Methods A retrospective analysis was conducted on the clinical data of 365 NSCLC patients who un-derwent lobectomy at the First Affiliated Hospital of University of Science and Technology of China from December 2020 to December 2023.The relationship between clinical characteristics and postoperative chronic cough was analyzed.The Chinese version of the Leicester Cough Questionnaire(LCQ-MC)scores were collected from the patients at 2 time points:1 day before surgery and 8 weeks after surgery.Patients were divided according to lymph node dissection methods,to explore the relation-ship between lymph node dissection and chronic cough after lobectomy.Additionally,patients were divided into chronic cough and non-chronic cough groups based on the presence of postoperative chronic cough,to investigate whether perioperative data,lymph node dissection methods,and lymph node dissection regions were influencing factors.Results Patients undergo-ing lobectomy were more likely to have chronic cough after surgery in the systematic lymph node dissection group than in the lymph node sampling group(P＜0.05).LCQ-MC scale evaluation showed that the psychological,physiological,social and to-tal score of the patients in systematic lymph node dissection group were significantly lower than those in lymph node sampling group(P＜0.05).Multivariate analysis showed that anesthesia time,operation site,lymph node dissection method,whether to perform upper mediastinal lymph node dissection,number of upper mediastinal lymph node dissection,whether to perform lower mediastinal lymph node dissection and total number of lymph node dissection were independent risk factors for postop-erative chronic cough in NSCLC patients(P＜0.05).Conclusion When NSCLC patients underwent lobectomy,lymph node sampling was associated with a significantly lower risk of chronic cough than systematic lymph node dissection.Dissecting lymph nodes in the upper and lower mediastinal regions and the number of lymph nodes dissected may increase the risk of postoperative cough and reduce the quality of life of patients after surgery.关键词
肺肿瘤/淋巴结清扫方式/慢性咳嗽/中文版莱斯特咳嗽问卷Key words
Lung neoplasms/Lymph node dissection method/Chronic cough/Mandarin Chinese version of the Leicester Cough Questionnaire引用本文复制引用
张泽锴,王高祥,陈郑玮,吴明胜,陈笑,李田,孙效辉,解明然..淋巴结清扫方式对非小细胞肺癌患者术后慢性咳嗽的影响[J].中国肺癌杂志,2025,28(6):434-440,7.基金项目
本研究受国家自然科学基金项目(No.81973643)资助 This study was supported by the grant from National Natural Science Foundation of China(No.81973643)(to Min-gran XIE). （No.81973643）
