摘要
Abstract
Objective To study the expression levels of Ki-67,P53 and C-myc proteins in elderly patients with colon cancer and their correlation with pathological features.Methods A total of 80 elderly patients with colon cancer admitted to our hospital from April 2021 to February 2022 were selected.The expression of Ki-67,P53 and C-myc proteins in colon cancer tissues and adjacent normal tissues was detected by im-munohistochemistry,and their correlation with pathological features was analyzed.Results The posi-tive expression rates of Ki-67,P53 and C-myc proteins in cancer tissues were significantly higher than those in adjacent normal tissues(P＜0.05).Univariate analysis showed that the positive rates of Ki-67,P53 and C-myc were not related to the patient's age,gender,maximum tumor diameter and histological type of tumor(P＞0.05),but were related to the degree of tumor differentiation,TNM stage,lymph node me-tastasis and depth of invasion(P＜0.05).Multivariate analysis showed that low degree of tumor differ-entiation,high TNM stage,lymph node metastasis and deep invasion depth were independent risk factors for the positive expression of Ki-67,P53 and C-myc proteins(P＜0.05),and there was a positive correla-tion between the positive expression of Ki-67,P53 and C-myc proteins(P＜0.05).Follow-up showed that the 3-year survival rates of patients with positive expression of Ki-67,P53 and C-myc proteins were lower than those of patients with negative expression(P＜0.05).Conclusion The positive expression rates of Ki-67,P53 and C-myc proteins in cancer tissues of elderly patients with colon cancer are relatively high,and are related to the degree of tumor differentiation,TNM stage,depth of invasion and lymph node me-tastasis.The positive expression rates can affect the prognosis of patients.Strengthening the detection of Ki-67,P53 and C-myc proteins is of certain significance for guiding clinical pathological evaluation and treatment.关键词
结肠癌/老年/Ki-67蛋白/P53蛋白/C-myc蛋白Key words
Colon cancer/Elderly/Ki-67 protein/P53 protein/C-myc protein
