摘要
Abstract
Objective To analyze the effect of esketamine on myocardial injury in patients after laparo-scopic radical resection of colon cancer.Methods From January 2022 to January 2024,total 136 patients who underwent laparoscopic radical resection of colon cancer in our hospital were selected and divided into an observation group and a control group by the random number table method,with 68 cases in each group.Both groups adopted the conventional surgical anesthesia plan.On this basis,the observation group was in-travenously injected with 0.5 mg/kg esketamine after anesthesia induction,and the rate of 0.5 mg/(kg·h)was maintained by intravenous pump injection until the end of the operation.The levels of myocardial injury markers,hemodynamic indexes and inflammatory factors at the time of entering the operating room(T1),5 minutes after anesthesia induction(T2),at the end of the operation(T3),and 24 hours after the opera-tion(T4),the postoperative pain levels and adverse cardiac events were compared between the two groups.Results There were no statistically significant differences in the levels of myocardial injury markers and inflammatory factors between the two groups at T1 and T2(P＞0.05).At T3 and T4,the serum levels of creatine kinase isoenzyme MB,high-sensitivity troponin Ⅰ,N-terminal pro-B-type natriuretic peptide,interleukin-6 and tumor necrosis factor-α in the observation group were lower than those in the control group(P＜0.05).At T2,T3 and T4,the heart rate and mean arterial pressure levels in the observation group were lower than those in the control group(P＜0.05).The pain score in the observation group was lower than that in the control group 6 hours after the operation(P＜0.05).The incidence of myocardial ischemia in the observation group was lower than that in the control group(P＜0.05).Conclusion Es-ketamine can enhance the levels of myocardial injury markers in patients after laparoscopic radical resection of colon cancer,improve the perioperative hemodynamics and inflammatory response,relieve postopera-tive pain,and reduce the probability of postoperative myocardial ischemia.关键词
结肠癌/腹腔镜根治术/艾司氯胺酮/心肌损伤Key words
Colon cancer/Laparoscopic radical resection/Esketamine/Myocardial injury
