中国感染控制杂志2025，Vol.24Issue(7)：906-911,6.DOI:10.12138/j.issn.1671-9638.20257099
主动筛查应用于重症监护病房内CRE监测的多中心研究
Application of active screening on carbapenem-resistant Enterobacterales monitoring in intensive care units:a multi-center study
摘要
Abstract
Objective To evaluate the effectiveness of active screening in improving the detection rate of carbape-nem-resistant Enterobacterales(CRE)in the intensive care units(ICUs).Methods From July 2023 to June 2024,active screening of rectal swab CRE was conducted on ICU patients in 10 hospitals.ICU patients who underwent ac-tive screening from July 2023 to June 2024 were selected as the study group,while those who did not undergo active screening from July 2022 to June 2023 were selected as the control group.Difference in CRE detection rates between the two groups of patients was compared.Results A total of 7 803 ICU patients were included in the study group,744 CRE strains were detected,with a detection rate of 9.53％,out of which 304 CRE strains were detected through routine detection(detection rate 3.90％),3 707 patients underwent active screen,440 CRE strains were detected(detection rate 11.87％).7 561 ICU patients were included in the control group,out of which 250 CRE strains were detected through routine detection,with a detection rate of 3.31％.There was a statistically significant difference in the overall detection rate of CRE between two groups of patients(x2=246.18,P＜0.001).In the study group,CRE detection rate of active screening(11.87％)was higher than that of routine detection(3.90％),with statistically significant difference(x2=264.26,P＜0.001).A total of 17 CRE strains were detected from the study group.The proportions of Klebsiella pneumoniae(80.92％vs 73.41％)and Serratia marcescens(2.30％vs0.23％)in the routine detection group were both higher than in the active screening group,while the proportion of Escherichia coli in the routine detection group was lower(8.22％vs 19.55％),all with statistically significant differences(all P＜0.05).Conclusion The prevalence of CRE in ICUs is relatively high,with a wide range of bac-terial species.Active screening can improve the detection rate of CRE.关键词
耐碳青霉烯类肠杆菌目细菌/主动筛查/重症监护病房/检出率/定植/CREKey words
carbapenem-resistant Enterobacterales/active screening/intensive care unit/detection rate/coloniza-tion/CRE分类
医药卫生引用本文复制引用
吕贻雨,丁韧,孟凡祥,李若洁,胡小骞,王雪萍,吴德全,吴贻乐,戚少云,沈诗华,刘璐,田真,徐志伟,方涛,郭翠英,李志萍..主动筛查应用于重症监护病房内CRE监测的多中心研究[J].中国感染控制杂志,2025,24(7):906-911,6.基金项目
国家自然科学基金项目(82202572) （82202572）
安徽高校自然科学研究重点项目(KJ2021A0321) （KJ2021A0321）
