局解手术学杂志2025，Vol.34Issue(7)：584-588,5.DOI:10.11659/jjssx.01E025124
经口经胃内镜下胆囊切除术的动物实验研究
Animal experimental study of transoral transgastric endoscopic surgery cholecystectomy
摘要
Abstract
Objective To investigate the feasibility and safety of transoral transgastric natural orifice transluminal endoscopic surgery(TG-NOTES)cholecystectomy in miniature pigs.Methods A total of 11 miniature pigs were selected as the experimental subjects and underwent TG-NOTES cholecystectomy.These pigs were divided into the Group A and Group B according to the surgical procedures.Among them,7 miniature pigs in the Group A underwent endoscopic cholecystectomy without dissecting the gallbladder triangle,while 4 miniature pigs in the Group B underwent endoscopic cholecystectomy after dissecting the gallbladder triangle.The success rate of surgery,the time of each stage of surgery,the incidence of complications,the success rate of cholecystectomy and the survival rate of miniature pigs in the two groups were counted.One miniature pig in the Group A and 4 miniature pigs in the Group B were selected for survival experiments.After surviving for 1 week,they were killed and dissected to observe the healing of incision and incidence of complications.Results The surgical survival rate of experimental animals was 100%,and the success rate of cholecystectomy was 100%.There was no significant difference in the surgical time,time of cut the stomach into the abdomen,time of gallbladder exploration or time of gallbladder removal of miniature pigs between the two groups(P>0.05).The time of ligating gallbladder artery of miniature pigs in the Group B was longer than that in the Group A,and the time of isdating gallbladder was shorter than that in the Group A,with statistically significant differences(P<0.05).There was no significant difference in the average number of complications of miniature pigs between the two groups(P>0.05).The dissection of animals after survival experiments revealed that the incisions healed well without serious complications.Conclusion This study successfully establishes the surgical model of TG-NOTES cholecystectomy,and confirms the safety and feasibility of TG-NOTES cholecystectomy.关键词
经自然腔道内镜手术/胆囊切除术/动物实验/可行性/并发症Key words
natural orifice transluminal endoscopic surgery/cholecystectomy/animal experiment/feasibility/complications分类
医药卫生引用本文复制引用
郑泓量,杨欢,聂绪彪,彭学,谯秋建,柏健鹰..经口经胃内镜下胆囊切除术的动物实验研究[J].局解手术学杂志,2025,34(7):584-588,5.基金项目
重庆英才创新领军人才项目(2022CQ010) （2022CQ010）
陆军军医大学2019重点扶持对象项目(2019R039) （2019R039）
