中国康复2025，Vol.40Issue(7)：418-421,4.DOI:10.3870/zgkf.2025.07.007
古琴音乐联合重复经颅磁刺激治疗脑卒中后抑郁的效果观察
Guqin music therapy combined with repetitive transcranial magnetic stimulation for post-stroke depression
摘要
Abstract
Objective:To investigate the therapeutic effect of combining Guqin music therapy with repetitive tran-scranial magnetic stimulation(rTMS)for patients with post-stroke depression.Methods:A total of 70 patients di-agnosed with post-stroke depression were randomly assigned to either an experimental group or a control group.Both groups received standard rehabilitation treatments along with rTMS(target site:left dorsolateral prefrontal cortex;frequency:10 Hz;intensity:80％-120％motor threshold;duration:20 min per session;frequency:once daily,5 times weekly for 6 weeks).Additionally,the experimental group underwent Guqin music therapy(listening to 15 classical pieces of Guqin music for 30 min each session,once daily,5 times weekly for 6 weeks).During the study period,one and two patients in the experimental group and the control group withdrew from the study at dif-ferent stages,resulting in a final sample size of 33 patients in the experimental group and 34 patients in the control group.The Hamilton depression scale(HAMD-24)was utilized to assess the depressive symptoms of patients before and after the intervention of 6 weeks.The National Institutes of Health stroke scale(NIHSS)was used to evaluate the degree of neurological deficit.Results:Post-treatment HAMD scores and NIHSS scores for both groups were significantly reduced compared to baseline levels(P＜0.01).The block factor,somatic anxiety factor,and sleep disorder factor scores showed significant reductions post-intervention(P＜0.01),with the experimental group dem-onstrating more pronounced improvements relative to the control group.The total effective rate in the experimental group was higher than in the control group.Conclusion:Guqin music therapy combined with rTMS demonstrates a significantly superior effect on post-stroke depression compared to rTMS alone,suggesting its potential as a safe and effective adjunctive treatment.关键词
脑卒中后抑郁/古琴音乐治疗/重复经颅磁刺激/非药物治疗Key words
post-stroke depression/Guqin music therapy/repetitive transcranial magnetic stimulation/non-phar-macological treatments分类
医药卫生引用本文复制引用
冯畑,王熠钊,赵洁玮,向世强..古琴音乐联合重复经颅磁刺激治疗脑卒中后抑郁的效果观察[J].中国康复,2025,40(7):418-421,4.基金项目
湖北本科高校省级教学改革研究项目(2023193) （2023193）
