中国康复理论与实践2025，Vol.31Issue(7)：781-789,9.DOI:10.3969/j.issn.1006-9771.2025.07.005
运动干预对帕金森病冻结步态效果的Meta分析
Effect of exercise on freezing of gait in Parkinson's disease:a meta-analysis
摘要
Abstract
Objective To evaluate the effect of exercise on freezing of gait in Parkinson's disease. Methods After constructing a PICO framework,randomized controlled trials(RCTs)about exercise for freezing of gait in Parkinson's disease were systematically retrieved from Web of Science,PubMed,Cochrane Library,Embase,CNKI,VIP and Wanfang Data,from the establishment of the databases to March,2025.The PEDro scale was used to evaluate the quality of literature,Stata 17.0 was used for meta-analysis,and GRADE was used to assess the evidence quality. Results A total of twelve RCTs involving 463 patients were included,with PEDro scale scores of five to eight.Exercise improved the scores of Freezing of Gait Questionnaire(FOGQ)(SMD=-0.61,95%CI-0.85～-0.36,P<0.001)and Unified Parkinson's Disease Rating Scale Ⅲ(UPDRSⅢ)(SMD=-0.84,95%CI-1.27～-0.41,P<0.001).Subgroup analysis revealed that the patients aged 59 to 68 years,the course of disease<six years,and male might get more benefit from exercise;exercise more than 30 minutes a time,more than three times a week,and lasting eight weeks or more might be better;and walking training alone might do less.GRADE was moderate for FOGQ,and low for UPDRSⅢ. Conclusion Exercise may relieve freezing of gait in Parkinson's disease,especially for male,younger people and people with shorter course of disease.Long term exercise(more than eight weeks),long session duration(more than 30 minutes)and high frequencies(more than three times a week),and mulit-strategy were recommended.关键词
帕金森病/运动/冻结步态/Meta分析Key words
Parkinson's disease/exercise/freezing of gait/meta-analysis分类
医药卫生引用本文复制引用
杜雯倩,张旭,陈继伟,王兴,朱昆..运动干预对帕金森病冻结步态效果的Meta分析[J].中国康复理论与实践,2025,31(7):781-789,9.基金项目
国家社会科学基金项目(No.22BTY076) National Social Science Fund of China(No.22BTY076) （No.22BTY076）
