中国康复理论与实践2025，Vol.31Issue(7)：822-829,8.DOI:10.3969/j.issn.1006-9771.2025.07.009
加速间歇性爆发性θ波刺激治疗卒中后抑郁的效果
Effect of accelerated intermittent theta burst stimulation on post-stroke depression
摘要
Abstract
Objective To explore the effect of accelerated intermittent theta burst stimulation(aiTBS)on post-stroke depression(PSD). Methods From July,2021 to July,2023,48 PSD patients in Beijing Bo'ai Hospital were randomly assigned to control group(n=16),high-frequency repetitive transcranial magnetic stimulation(HF-rTMS)group(n=16)and aiTBS group(n=16).aiTBS group received left-sided aiTBS treatment at dorsolateral prefrontal cortex(DLPFC),HF-rTMS group received left-sided 10 Hz rTMS treatment at DLPFC,and the control group received left-sided sham stimulation treatment,for three weeks.They were evaluated with the Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Rating Scale(HAMA)and Beck Depression Inventory(BDI)before and after treat-ment,and one month of follow-up. Results One case dropped down in each group.The inter-group effect,intra-group effect and interaction effect of HAMD,HAMA and BDI scores were all significant(F>3.235,P<0.05).The post-hoc test results showed that the scores of HAMD,HMMA and BDI were lower in HF-rTMS group and aiTBS group than in the control group(P<0.05),and no significant difference was found between HF-rTMS group and aiTBS group(P>0.05).There was significant difference in the effective rate of depression improvement among three groups(χ2=7.834,P=0.019),the effective rate was higher in aiTBS group than in the control group(P<0.017),and no significant dif-ference was found between HF-rTMS group and aiTBS group(P>0.017). Conclusion aiTBS can improve the depression and anxiety symptoms of patients with PSD,with shorter treatment time,compared with HF-rTMS.关键词
卒中后抑郁/间歇性爆发性θ波刺激/汉密尔顿抑郁量表/汉密尔顿焦虑量表/贝克抑郁自评量表Key words
post-stroke depression/intermittent theta burst stimulation/Hamilton Depression Rating Scale/Hamilton Anxiety Rating Scale/Beck Depression Inventory分类
医药卫生引用本文复制引用
山磊,刘影,张欣,迟茜茜,朱晓敏..加速间歇性爆发性θ波刺激治疗卒中后抑郁的效果[J].中国康复理论与实践,2025,31(7):822-829,8.基金项目
中国康复研究中心面上课题(No.2021zx-17) China Rehabilitation Research Center Project(General)(No.2021zx-17) （No.2021zx-17）
