中国临床药理学杂志2025，Vol.41Issue(11)：1501-1505,5.DOI:10.13699/j.cnki.1001-6821.2025.11.001
阿魏酸哌嗪联合连续性肾替代疗法治疗急性肾衰竭患儿的临床研究
Clinical trial of piperazine ferulate combined with continuous renal replacement therapy in the treatment of children with acute renal failure
摘要
Abstract
Objective To observe the clinical efficacy and safety of ferulic acid piperazine tablets combined with continuous renal replacement therapy in the treatment of children with acute renal failure.Methods Children with acute renal failure were randomly divided into control group and treatment group.Both groups were given basic treatment,based on which,the control group was given continuous renal replacement therapy;the treatment group was given piperazine ferulate tablets 100 mg per time,orally,tid,on the basis of control group.Two groups were treated for 2 weeks.The clinical efficacy,renal function,levels of renal injury markers and safety were compared between the two groups.Results Treatment group was enrolled 85 cases,2 cases dropped out,and 83 cases were finally included in the statistical analysis.Control group was enrolled 84 cases,3 cases dropped out,and 81 cases were finally included in the statistical analysis.After treatment,the total effective rates of treatment and control groups were 92.77％(77 cases/83 cases)and 81.48％(66 cases/81 cases)with statistically significant difference(P＜0.05).After treatment,the serum creatinine levels of treatment and control groups were(120.35±17.12)and(148.12±20.03)μmoL · L-1;the blood urea nitrogen levels were(12.29±2.14)and(15.64±3.01)μmoL · L-1;the β2-microglobulin levels were(1.87±0.25)and(2.14±0.39)mg · L-1;the 24-h urinary protein quantification were(0.94±0.31)and(1.24±0.47)g · 24 h-1;N-acetyl-β-D-glucosidase contents were(17.03±2.98)and(20.36±3.51)U · L-1;the renal injury molecule 1 contents were(1.62±0.27)and(2.09±0.32)μg · L-1;the neutrophil gelatinase-associated lipid transport protein contents were(50.36±8.13)and(59.23±10.14)μg · L-1,respectively,and the differences were all statistically significant(all P＜0.05).The adverse drug reactions of treatment group were nausea,vomiting and abdominal distension,while those in the control group were dizziness,nausea and vomiting.The total incidences of adverse drug reactions in the treatment and control groups were 7.23％ and 4.94％without significant difference(P＞0.05).Conclusion Ferulic acid piperazine tablets combined with continuous renal replacement therapy have definitive clinical efficacy in the treatment of children with acute renal failure,which can significantly improve the renal function of children,reduce renal injury,without increasing the incidence of adverse drug reactions.关键词
阿魏酸哌嗪片/连续性肾替代疗法/急性肾衰竭/临床疗效/安全性评价Key words
piperazine ferulate tablet/continuous renal replacement therapy/acute renal failure/clinical effect/safety evaluation分类
医药卫生引用本文复制引用
柴彦艳,盛瑶,金丹群,童文佳,王云,邓芳..阿魏酸哌嗪联合连续性肾替代疗法治疗急性肾衰竭患儿的临床研究[J].中国临床药理学杂志,2025,41(11):1501-1505,5.基金项目
安徽省临床医学研究转化专项基金资助项目(202304295107020063) （202304295107020063）
