中国临床药学杂志2025，Vol.34Issue(6)：476-480,5.DOI:10.19577/j.1007-4406.2025.06.015
舍曲林血药浓度影响因素研究进展
Research progress on influencing factors of sertraline blood concentration
摘要
Abstract
As a potent and selective serotonin reuptake inhibitor(SSRI)widely used in clinical practice,sertraline has significant inter-individual differences in its steady-state plasma concentration under conventional doses.This difference stems from multifactorial effects,including dose,age,liver function status,concomitant medication status,and drug metabolism-related factors such as genetic polymorphisms.This review systematically analyzed the key factors affecting sertraline blood concentration(including dose,demographic characteristics,physiopathological status,and drug interactions),aiming to provide evidence-based basis for the clinical formulation of individualized dosing regimens,so as to optimize the treatment effect and ensure drug safety.关键词
舍曲林/血药浓度/影响因素Key words
sertraline/blood drug concentration/influencing factor分类
医药卫生引用本文复制引用
自雪梅,王晶晶..舍曲林血药浓度影响因素研究进展[J].中国临床药学杂志,2025,34(6):476-480,5.基金项目
国家自然科学基金(编号82460737) （编号82460737）
云南省应用基础研究-昆明医科大学联合专项(编号202401AY070001-034) （编号202401AY070001-034）
