中国免疫学杂志2025，Vol.41Issue(7)：1537-1542,6.DOI:10.3969/j.issn.1000-484X.2025.07.001
Sema6D对免疫细胞调控作用的研究进展
Research progress on regulatory effect of Sema6D on immune cells
摘要
Abstract
Sema6D,a member of Semaphorin protein family,is a type Ⅰ single-pass transmembrane protein whose expres-sion vary across different tissues.Known ligands for Sema6D include transmembrane proteins PlexinA1 and PlexinA4.Upon binding its ligands,intracellular domain of Sema6D recruits and activates tyrosine kinase Abl,thereby regulating cellular activities such as migration,adhesion and polarization.Early research primarily focused on role of Sema6D in regulating nervous system.Recent studies,however,have revealed that Sema6D is expressed on various immune cells and participates in modulating immune functions.Sema6D can mediate anti-inflammatory polarization of macrophages through metabolic reprogramming,inhibit secretion of pro-inflammatory cyto-kines by dendritic cells while promoting their migration,and enhance proliferation of CD4⁺T cells.Furthermore,Sema6D itself can act as a ligand,regulating function of PlexinA1⁺ type 2 innate lymphoid cells and PlexinA4⁺T cells.This review summarizes recent advances in understanding how Sema6D regulates functions of these immune cells,highlighting its multifaceted roles within immune system and providing novel insights into immune homeostasis and disease mechanisms.关键词
Sema6D/免疫细胞/调控作用Key words
Sema6D/Immune cells/Regulatory role分类
医药卫生引用本文复制引用
王莺杰,彭慧..Sema6D对免疫细胞调控作用的研究进展[J].中国免疫学杂志,2025,41(7):1537-1542,6.基金项目
科技部国家重点研发计划青年项目(2020YFA0804100) （2020YFA0804100）
合肥综合性国家科学中心大健康研究院前沿交叉科学与生物医学研究所资助项目(QYZD20220005). （QYZD20220005）
