中国免疫学杂志2025，Vol.41Issue(7)：1656-1664,9.DOI:10.3969/j.issn.1000-484X.2025.07.017
肿瘤相关巨噬细胞介导肺癌耐药的机制及中药干预研究进展
Mechanism of tumor-associated macrophages in mediating drug resistance in lung cancer and research progress of traditional Chinese medicine intervention
摘要
Abstract
Lung cancer is one of the most prevalent malignant tumors,which incidence and mortality rates increasing annually.Development of drug resistance is a primary factor contributing to treatment failure.Tumor-associated macrophages(TAMs),as key immune cells within tumor microenvironment(TME),play a significant role in the emergence and progression of drug resistance in tu-mors.TAMs can polarize into two distinct subtypes,M1 and M2,in response to diverse signaling stimuli.Research indicates that M2 TAMs are closely associated with poor prognoses in lung cancer,facilitating drug resistance through mechanisms such as promoting angiogenesis,enabling immune evasion,inducing stem cell-like characteristics in tumors,modulating relevant signaling pathways,and secreting cytokines.Traditional Chinese medicine(TCM)is characterized by its multi-target approach and minimal toxic side effects,it has been shown to enhance tumor sensitivity to drugs,slow malignant progression,and extend patient survival.This paper reviews the relationship between TAMs and lung cancer drug resistance while summarizing current research on TCM and their active components that regulate TAM activity to mitigate drug resistance in lung cancer,aiming to provide new insights for targeting TAMs in this context.关键词
肺癌/肿瘤相关巨噬细胞/耐药/中药Key words
Lung cancer/Tumor-associated macrophages/Drug-resistance/Traditional Chinese medicine分类
医药卫生引用本文复制引用
王天琪,夏金婵,曾华辉,许莹雪,薛忠慧,苏梦娇,韩佳乐..肿瘤相关巨噬细胞介导肺癌耐药的机制及中药干预研究进展[J].中国免疫学杂志,2025,41(7):1656-1664,9.基金项目
河南省科技发展计划项目(222300420482). （222300420482）
